石衫碱甲

品名:石衫碱甲

检测方式: HPLC

规格:石衫碱甲1%  5%  98% HPLC

分子式: C15H18N2O

分子量: 242.316

CAS 号.: 120786-18-7

石杉碱甲,用于中、老年良性记忆障碍及各型痴呆、记忆认知功能及情绪行为障碍。尚可用于治疗重症肌无力。

石衫碱甲的功效:

 

1.石杉碱能改善阿尔茨海默病、多发性心脏痴呆和老年痴呆患者的记忆、思维和行为功能,并通过阻断其分解增加神经递质乙酰胆碱的水平。

 

2。它还可以保护神经元免受谷氨酸中毒引起的细胞 ,并保护神经元免受战争中使用的化学神经制剂(如梭曼)的某些影响。

 

3.在一项随机对照试验中,它也是AD对认知功能影响的治疗方法。

参考文献:

  1. 1.  

    Bei D, Tang X, He X (2000) Curr Med Chem 7:355–374 

  2. 2.  

    Howes MJ, Perry NS, Houghton PJ (2003) Phytother Res 17:1–18. 

  3. 3.  

    Ye JW, Cai JX, Wang LM, Tang XC (1999) J Pharmacol Exp Ther 288:814–819

  4. 4.  

    Zangara A (2003) Pharmacol Biochem Behav 75:675–686.

  5. 5.  

    Lallement G, Baille V, Baubichon D, Carpentier P, Collombet JM, Filliat P, Foquin A, Four E, Masqueliez C, Testylier G, Tonduli L, Dorandeu F (2002) Neurotoxicology 23:1–5.

  6. 6.  

    Ye JC, Zeng S, Zhang WG, Chen GS (2005) J Chromatogr B Analyt Technol Biomed Life Sci 817:187–191.  

  7. 7.  

    Qian BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS (1995) Zhongguo Yao Li Xue Bao 16:396–398

  8. 8.  

    Wei GL, Xiao SH, Lu R, Liu CX (2006) J Chromatogr B Analyt Technol Biomed Life Sci 830:120–125.

  9. 9.  

    Ye JC, Zeng S, Zhang GL, Chen GS (2008) Int J Pharm 356:187–192

  10. 10.  

    Yue P, Tao T, Zhao Y, Ren JF, Chai XY (2007) J Pharm Biomed Anal 44:309–312.

  11. 11.  

    Chu DF, Liu WH, Li YX, Li PF, Gu JK, Liu K (2006) Planta Med 72:552–555. 

  12. 12.  

    Fu XD, Ping QN, Gao YL, Guo JF (2004) J China Pharm Univ 35:235–238

  13. 13.  

    Liu X, Li D, Wang XL, Chen CL (2006) Fudan Univ J Med Sci 33:247–250

  14. 14.  

    Li YX, Jiang XH, Lan K, Wang L (2007) Biomed Chromatogr 21:15–20.

  15. 15.  

    Li C, Du FF, Yu C, Xu X, Zheng J, Xu F, Zhu DY (2004) Rapid Commun Mass Spectrom 18:651–656.

  16. 16.  

    Wang YW, Chu DF, Gu JK, Fawcett JP, Wu Y, Liu WH (2004) J Chromatogr B Analyt Technol Biomed Life Sci 803:375–378.  

  17. 17.  

    Li W, Li JH, Hu Q (2008) Biomed Chromatogr 22:354–360.  

  18. 18.  

    Hameda AB, Taborsky P, Pena-Mendez EM, Havel J (2007) Talanta 72:780–784. 

  19. 19.  

    Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2001