积雪草提取物中含有多种三萜类，其中包含α-香树脂醇结构。主要成分为积雪草甙，羟基积雪草甙，外观棕黄色至白色精细粉末，口感微苦。对于治疗湿热黄疸，中暑腹泻，砂淋血淋，痈肿疮毒，跌扑损伤都有极好的效果。

积雪草提取物及积雪草经常被外用于祛疤痕促进伤口愈合
资料显示，积雪草又叫雷公根，属于多年生草本匍匐植物。因其叶子酷似马蹄状或半个铜钱，又称“马蹄草”、“连钱草”。原产于印度，喜生于湿润的河岸、沼泽、草地中。现已广泛分布于热带、亚热带区，中国也有，主要分布于长江以南各省。

我国应用积雪草的历史极其悠久， 古籍《神农本草经》就有记载积雪草对于清热解毒、利湿消肿等方面的药用功效。在中国和印度，积雪草经常被外用于祛疤痕、促进伤口愈合。随着科技的进步以及人皆有之的爱美之心，积雪草提取物开始在护肤品、化妆品等领域被广泛使用。

积雪草中的有效成分 1948 年就已分离出来，是一系列三萜类化合物，包含了皂苷元(积雪草酸和羟基积雪草酸) ，还有它们的储存形式葡萄糖甙(积雪草苷、羟基积雪草苷)。此外，积雪草中还有多酚以及黄酮类化合物。正是由于积雪草中的这些化学成分，使得积雪草提取物具有多种功效。与积雪草有关的成分有：积雪草根提取物、积雪草花/叶/茎提取物、积雪草提取物、积雪草叶提取物、积雪草苷。
上禾生物积雪草提取物中的有效成分主要是积雪草苷和羟基积雪草苷，而关于积雪草祛疤痕、促进伤口愈合等作用已经有几千年的历史了。现代研究表明，积雪草相关提取物有促进皮肤纤维细胞生长、促进皮肤胶原合成、抑制炎症、抑制基质金属蛋白酶活性的作用。所以积雪草对皮肤有损伤修复、减缓皮肤溃烂、祛疤修复、促进衰老肌肤新生、祛除妊娠纹等功效。

产品详询：13657416805

产品文献：

1. 1.Berg, J., T. John, and L. Stryer. 2001. Biochemistry. Freeman WH and Co., New York 

2. 2.Bonfill, M., S. Mangas, R.M. Cusidü, L. Osuna, M.T. Piñol, and J. Palazün. 2006. Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. Biomed. Chromatogr. 20:151–153. 

3. 3.Bonner, J. 1972. The isoprenoids, p. 665–690. In: J. Bonner and J.E. Varner (eds.). Plant biochemistry. Academic Press, New York.

4. 4.Gunther. B. and H. Wagner. 1996. Quantitative determination of triterpenes in extracts and phytoparations of Centella asiatica (L.) Urban. Phytomedicine 3:59–65. 

5. 5.Hsu, Y.L., P.L. Kuo, L.T. Lin, and C.C. Lin. 2005. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J. Pharmacol. Exp. Ther. 313:333–344.

6. 6.Inamdar, P.K., R.D. Yeole, A.B. Ghogare, and N.J. Souza. 1996. Determination of biologically active constituents in Centella asiatica. J. Chromatogr. A 742:127–130.

7. 7.Jian, Z., L.C. Davis, and R. Verpoorte. 2005. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv. 23:283–333.

8. 8.Joshi, S.G. 2000. Medicinal plants. Oxford & IBH Publishing Co., Pvt, Ltd., New Delhi, India.

9. 9.Kiong, A.L.P., M. Mahmood, N.M. Fadzillah, and S.K. Daud. 2005. Effects of precursor supplementation on the production of triterpenes by Centella asiatica callus cultures. Pak. J. Biol. Sci. 8:1160–1169

10. 10.Memon, A.R., Q.Y. Chen, and W.F. Boss. 1989. Inositol phospholipids activate plasma membrane ATPase in plants. Biochem. Biophys. Res. Commun. 162:1295–1301 

11. 11.Nelson, D.L. and M.M. Cox. 2001. Lehninger’s principles of biochemistry. Freeman WH and Co., New York. p. 1040–1059.

12. 12.Park, B.C., K.O. Bosire, E.S. Lee, Y.S. Lee, and J.A. Kim. 2005. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 218:81–90.

13. 13.Perassolo, M., C. Quevedo, V. Busto, F. Ianone, A.M. Giulietti, and J. Rodriguez Talou. 2007. Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures. Enzyme Microb. Technol. 41:181–185. 

14. 14.Schaneberg, B.T., J.R. Mikell, E. Bedir, and I.A. Khan. 2003. An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. Pharmazie 58:381–384.

15. 15.Seidel, V., J. Windhövel, G. Eaton, A.W. Alfermann, R.R. Arroo, M. Medarde, M. Petersen, and J.G. Woolley. 2002. Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta. 215: 1013–1039. 

16. 16.Singh, B. and R.P. Rastogi. 1969. A re-investigation of the triterpenes of Centella asiatica. Phytochemistry 8:917–921. 

17. 17.Sumaryono, W., P. Proksch, T. Hartmann, M. Nimtz, and V. Wray. 1991. Induction of rosmarinic acid accumulation in cell suspension cultures of Orthosiphon aristatus after treatment with yeast extract. Phytochemistry 30:3267–3271. 

18. 18.Suzuki, T., H. Mori, T. Yamame, and S. Shimuzu. 1985. Automatic supplementation of minerals in fed-batch culture to high cell mass concentration. Biotech. Bioeng. 27:192–201.