【產品名稱】：杜仲綠原酸

 

【英 文 名】：Chlorogenic acid 

 

【別    名】：氯原酸，咖啡鞣酸，3 —咖啡酰奎尼酸Cyclohexanecarboxylic acid

 

【拉 丁 名】：Eucommia ulmoides Oliv.

 

【提取部位】：為杜仲雄株樹Eucommia ulmoides Oliv.花蕊。

 

【主要成分】：杜仲雄花含有木質素類，環烯醚萜類、苯丙素類XX活性成分（如京尼平甙酸、綠原酸、桃葉珊瑚甙）、松脂醇雙糖甙、黃酮（槲皮素）、氨基酸、多糖以及礦質元素Zn、Mn、Cu、Fe、Ca、P、B、Mg、K等。

 

【含    量】：3%-98%，98%（本品）

 

【檢測方法】：HPLC

 

【分 子 式】：C16H18O9

 

【分 子 量】：354.31

 

【C A S 號】：327-97-9 

 

【EINECS登錄號】：206-325-6

 

【外   觀】：本品為白色粉末。

 

【物理性狀】：25 ℃水中溶解度為4%，熱水中溶解度更大；易溶于乙醇及丙酮，極微溶于醋酸乙酯，難溶于三氯甲烷、 、苯等親脂性有機溶劑。

 

【目    數】：80目

 

【儲    存】：置於陰涼乾燥、避光，避高溫處。

 

【包    裝】：1kg/鋁箔袋， 25kg/紙板桶(內用雙層塑料袋，外套紙板桶)。

 

【保 質 期】：24個月。

杜仲綠原酸來源於杜仲科植物杜仲（Eucomma Umoides Oliv）葉，採用純水提取、沉降、精密過濾，再經樹脂吸附分享等工藝精製而成。

 

[性狀]產品冷水中溶解度小，易溶于熱水、乙醇和丙酮，純品為針狀結晶，分子量354.3，在微酸性、低溫、避光條件下，性質穩定，UV 吸收峰324mm（水溶液）左右。

[用途]本品具有抗菌、消炎、解毒、利膽、降壓及升高白細胞及顯著增加胃腸蠕動和促進胃液分泌等藥理作用，對大腸桿菌、金色葡萄球菌、肺炎球菌和病毒有較強的抑制和殺滅作用，對急性咽喉炎症及皮膚病有明顯療效，臨床上用於治療急性細菌性感染疾病及放、化療時所致的白細胞減少症，對月經過多、子宮功能性出血有良好的止血效果，還具有腎上腺素類作用。

杜仲綠原酸的主要藥理作用有：

1、降壓作用

2、補腎、增強機體免疫作用

3、抗氧化、抗衰老、抗肌肉骨骼老化

4、抗菌、抗病毒

 

參考文獻：

1.Liu QR (2005) Chin J Acta Phytotax Sin 43:178–180 chlorogenic acid
2.Agnese AM, Montoya SN, Espmar LA, Cabrera JL (1999) Biochem Syst Ecol 27:739–742
3.Gutzeit D, Winterhalter P, Jerz G (2007) J Chromatogr A 1172:40–46.
4.Ito Y (2005) J Chromatogr A 1065:145–168. 
5.Xiao XH, Guo ZN, Deng JC, Li GK (2009) Sep Purif Technol 68:250–256.
6.Li BX, He J, Evans DG, Duan X (2004) Appl Clay Sci 27:199–207.
7.Lu Z, Duan X (2008) Chin J Catal 29:839–856
8.Modabber AK, Choi CL, Lee DH, Parka M, Limb BK, Lee JY, Choi J (2007) J Phys Chem Solids 68:1591–1597
9.Xie QQ, Wei Y, Zhang GL (2010) Sep Purif Technol 72:229–233.
10.Wei Y, Gao YL, Zhang K, Ito Y (2010) J Liq Chromatogr Rel Technol 33:837–845. 
11.Ni ZM, Xing FF, Wang X, Cao GT (2008) Appl Clay Sci 40:72–80. 
12.Zhang WF, Li DQ, Sun Q, Evans DG, Duan X (2004) Chin Univ 25:1799–1803
13.Eskin, M. M. A., Hochn, E., and Frenkel, C. (1978) A simple and rapid quantitative method for total phenols. J. Agric. Food Chem. 26, 973–975.
14.Chlorogenic Acids
Small quantities of free quinic acid occur in green coffee beans. A greater quantity of quinic acid occurs as a series of esters (collectively) generally known as chlorogenic acids (CGA). Possibly the first repor...
M. N. Clifford in Coffee (1985)
15.Determination of baicalin, chlorogenic acid and forsythin in Chinese medicinal preparation by capillary electrophoresis
Xiangjun Li, Yuping Zhang, Zhuobin Yuan in Chromatographia (2002)
16.Isolation of Chlorogenic Acid from Flaveria bidentis (L.) Kuntze by CCC and Synthesis of Chlorogenic Acid-Intercalated Layered Double Hydroxide
Preparative counter-current chromatography (CCC) was successfully used for isolation and purification of chlorogenic acid from Flaveria bidentis (L.) Kuntze with a solvent system composed of ethyl acetate–methano...
Yun Wei, Yali Gao, Qianqian Xie, Guoliang Zhang, Weidong Fu in Chromatographia (2011)
17.Validation of an isocratic HPLC method based on the use of ABZ+ plus phase for the simultaneous determination of methylxantines, chlorogenic acid, some hydroxy-benzoic and hydroxy-cinnamic acids. Application to cocoa, coffee, tea and cola-drinks
M. Arlorio, J. D. Coïsson, A. Martelli in Chromatographia (2001)
18.The effect of post-exercise caffeine and chlorogenic acid supplementation on blood glucose disposal and insulin sensitivity
Jason R Beam, Ann L Gibson, Chad M Kerksick… in Journal of the International Society of Sp… (2013)
19.Correction to: Antiacetylcholinesterase activity and docking studies with chlorogenic acid, cynarin and arzanol from Helichrysum stoechas (Asteraceae)
The original version of this article unfortunately contained an error in the article title. There is a incorrect term Lamiaceae inadvertently appeared in the title, instead it should be Asteraceae.
Letícia Silva, Ana Margarida Rodrigues, Marina Ciriani… in Medicinal Chemistry Research (2018)

20.Correction to: the Inhibitory Effect of Chlorogenic Acid on Lipid Oxidation of Grass Carp (Ctenopharyngodon idellus) during Chilled Storage
The original version of this article unfortunately contained some mistakes.

Qiongju Cao, Hongying Du, Yuan Huang, Yang Hu, Juan You… in Food and Bioprocess Technology (2020)

21.Effect of Photoperiod and Chlorogenic Acid on Morphogenesis in Leaf Discs of Streptocarpus Nobilis
Leaf discs from vegetative plants greatly increase their phenolic content when cultivated in vitro. Under long days the values remained constant, and were higher when compared with short days cultures. Under shor...

E.I.S. Floh, W. Handro in Biologia Plantarum (2001)

22.Simultaneous determination of geniposidic acid, chlorogenic acid and geniposide in eucommia by HPLC
A high performance liquid chromatography (HPLC) method was established for simultaneous determination of geniposidic acid, chlorogenic acid and geniposide in eucommia. Detection at 240...3OH volume fraction, acidic

Yu-ping Li, Xiao-qing Chen, Mi-jun Peng… in Journal of Central South University of Tec… (2003)

23.Establishment of a simple method for purification of high purity chlorogenic acid from immature fruit of pear (Pyrus pyrifolia Nakai)
Chlorogenic acid [3-(3,4-dihydroxycinnamoyl)quinic acid, CGA] is one of the main...Pyrus pyrifolia...Nakai cv. Chuhwangbae) which contains CGA in high concentration. The 80 % MeOH extract (1.4 g) of immature pear...

Sang Won Lee, Yu Geon Lee, Jeong-Yong Cho… in Journal of the Korean Society for Applied … (2015)

24.Peroxidase activity against guaiacol, NADH, chlorogenic acid, ferulic acid and coniferyl alcohol in root tips of Lotus japonicus and L. corniculatus grown under low pH and aluminium stress
The purpose of this study was to examine the impact of low pH and Al stress on the apoplastic production of H2O2 and POD activity against guaiacol, ferulic acid, coniferyl alcohol, NADH and chlorogenic acid in th...

Veronika Zelinová, Igor Mistrík, Peter Paľove-Balang, Ladislav Tamás in Biologia (2010)

25.High-Performance Liquid Chromatographic Method for Determination and Pharmacokinetic Study of Chlorogenic Acid in the Plasma of Rats After Administration of the Chinese Medicinal Preparation Luying Decoction
A simple and sensitive high-performance liquid chromatographic method has been developed for determination of chlorogenic acid in rat plasma. Chlorogenic acid was extracted from plasma samples with methanol....18

Q. -F. Liao, Y. Jia, Q. -T. Gao, X. -H. Chen, X. -J. Tan, K. -S. Bi in Chromatographia (2005)

26.Photo-induced changes in the concentrations of individual chlorogenic acid isomers in potato (Solanum tuberosum) tubers and their complexation with ferric ions
Changes in the concentrations of 3-, 4- and 5-caffeoylquinic acids in potato tubers exposed to light have ... to 48 hours the observed increases in total chlorogenic acid content was due primarily to an increase ...

D. W. Griffiths, H. Bain in Potato Research (1997)

27.Validation of an isocratic HPLC method based on the use of ABZ+ plus phase for the simultaneous determination of methylxantines, chlorogenic acid, some hydroxy-benzoic and hydroxy-cinnamic acids. application to cocoa, coffee, tea and cola-drinks
Validation of an isocratic HPLC method for determination of methylxantines, chlorogenic acid and some hydroxy-benzoic/cinnamic acids in nervine foods and beverages is described....+ Plus phase permitted complete ...

M. Arlorio, J. D. Coïsson, A. Martelli in Chromatographia (2000)

28.Simultaneous identification of rutin, chlorogenic acid and gallic acid in Moringa oleifera by densitometric high-performance thin-layer chromatography method
An HPTLC (high-performance thin-layer chromatography) method was carried out to develop a feasible, simple and accurate method for the estimation of exact concentration of flavonoids in Moringa oleifera. The simu...

Pravej Alam, Prawez Alam… in JPC – Journal of Planar Chromatography – M… (2020)

29.Shock effects on plants: Tannic acid and chlorogenic acid in yam roots
Les tanins de l'acide chlorogénique s'accumulent immédiatement après que les racines d'ignames ont été soumises à des chocs de 10 à 44 ϕ (0.6–2.66 kg/cm2), consistant en une pulsation de la pression comparable à ...

Sylvia A. Murray in Experientia (1971)

30.Large-scale cultivation of adventitious roots of Echinacea purpurea in airlift bioreactors for the production of chichoric acid, chlorogenic acid and caftaric acid
Adventitious roots of Echinacea purpurea...were cultured in airlift bioreactors (20 l, 500 l balloon-type, bubble bioreactors and 1,000 l drum-type bubble bioreactor) using Murashige and Skoog (MS) medium with 2 ...

Chun-Hua Wu, Hosakatte Niranjana Murthy, Eun-Joo Hahn… in Biotechnology Letters (2007)