中文名 橄欖苦甙
外文名 olive
拉丁文名 Olea europaea L
有效成分:橄欖苦甙
規格:40%
檢測方式:HPLC
Cas號:32619-42-4
英文名:Oleuropein
別名:橄欖苦苷
化學名:[2S-(2,3E,4)]-3-Ethylidene-2-(-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid 2-(3,4-dihydroxyphenyl)ethyl ester
成分分類: 裂環烯醚萜類
分子量:540.51.
分子式:C25H32O13
物理性質:微小結晶(乙酸乙酯)。熔點87~89℃。易吸濕。旋光度-147°(c=1,水、乙醇或丙醇),呈變旋作用,旋光度-127°(9h后,水中),易溶于乙醇、丙酮、冰醋酸,5%NaOH溶液等,可溶于水、丁醇、乙酸乙酯、醋酸丁酯等,幾乎不溶于 、石油醚、氯仿、四氯化碳等。
應用
1、製藥 用於製造治療病毒、細菌、原生動物類、寄生虫和吸血虫等所引起的疾病的新藥,和治療感冒的新藥。
2、保健食品 在歐美等國家,橄欖葉提取物主要做為膳食補充劑,用於調節免疫力。
3、護膚品 高含量的橄欖苦甙主要用於護膚品,可以保護皮膚細胞不受紫外線的傷害,有效維持肌膚柔嫩與彈性,達到扶膚、嫩膚的功效。高含量橄欖苦甙80%專門為護膚品設計,其有效成分高,顏色淺,非常適合化妝品配方設計。
產品詳詢:13657416805
González-Correa JA, Muñoz-Marín J, Arrebola MM, Guerrero A, Narbona F, López-Villodres JA, De La Cruz JP (2007) Dietary virgin olive oil reduces oxidative stress and cellular damage in rat brain slices subjected to hypoxia–reoxygenation. Lipids 42(10):921–929
González-Correa JA, Navas MD, Lopez-Villodres JA, Trujillo M, Espartero JL, De La Cruz JP (2008) Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia–reoxygenation. Neurosci Lett 446(2):143–146
Kuem N, Song SJ, Yu R, Yun JW, Park T (2014) Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings. Mol Nutr Food Res 58(11):2166–2176
Dekanski D, Selaković V, Piperski V, Radulović Ž, Korenić A, Radenović L (2011) Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine 18(13):1137–1143
Bu Y, Rho S, Kim J, Kim MY, Lee DH, Kim SY, Choi H, Kim H (2007) Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neurosci Lett 414(3):218–221
Mohagheghi F, Bigdeli MR, Rasoulian B, Zeinanloo AA, Khoshbaten A (2010) Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion. Sci World J 10:1180–1191
De La Cruz JP, Del Río S, Arrebola MM, López-Villodres JA, Jebrouni N, González-Correa JA (2010) Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus. Neurosci Lett 471(2):89–93
Pitozzi V, Jacomelli M, Zaid M, Luceri C, Bigagli E, Lodovici M, Ghelardini C, Vivoli E, Norcini M, Gianfriddo M, Esposto S (2010) Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats. Br J Nutr 103(11):1674–1683
Zare L, Esmaeili-Mahani S, Abbasnejad M, Rasoulian B, Sheibani V, Sahraei H, Kaeidi A (2012) Oleuropein, chief constituent of olive leaf extract, prevents the development of antinociceptive tolerance through inhibition of -induced L-type calcium channel overexpression. Phytother Res 26(11):1731–1737
Esmaeili Mahani S, Zare L (2013) Olive (Olea europaea L.) leaf extract and its main component (oleuropein) mitigate the development of physical dependence in rats. Physiol Pharmacol 16(4):360–370
Lauretti GR, Ahmad I, Pleuvry BJ (1994) The activity of analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole. Neuropharmacology 33(2):155–160
Foote F, Gale K (1984) Proconvulsant effect of on seizures induced by pentylenetetrazol in the rat. Eur J Pharmacol 105(1):179–184
Homayoun H, Khavandgar S, Namiranian K, Gaskari SA, Dehpour AR (2002) The role of nitric oxide in anticonvulsant and proconvulsant effects of in mice. Epilepsy Res 48(1):33–41
Khavandgar S, Homayoun H, Dehpour AR (2003) Mediation of nitric oxide in inhibitory effect of against electroshock-induced convulsions in mice. Pharmacol Biochem Behav 74(4):795–801
de la Puerta R, Domínguez ME, RuÍz-GutÍerrez V, Flavill JA, Hoult JR (2001) Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission. Life Sci 69(10):1213–1222
Visioli F, Galli C (1994) Oleuropein protects low density lipoprotein from oxidation. Life Sci 55(24):1965–1971
Visioli F, Bellosta S, Galli C (1998) Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci 62(6):541–546
Visioli F, Poli A, Gall C (2002) Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 22(1):65–75
Honar H, Riazi K, Homayoun H, Demehri S, Dehghani M, Vafaie K, Ebrahimkhani MR, Rashidi N, Gaskari SA, Dehpour AR (2004) Lithium inhibits the modulatory effects of on susceptibility to pentylenetetrazole-induced clonic seizure in mice: involvement of a nitric oxide pathway. Brain Res 1029(1):48–55
Majewska MD, Bell JA, London ED (1990) Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate. Brain Res 537(1):328–332
Park S, Choi Y, Um SJ, Yoon SK, Park T (2011) Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice. J Hepatol 54(5):984–993
Shafaroodi H, Baradaran N, Moezi L, Dehpour S, Kabiri T, Dehpour AR (2011) sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors. Epilepsy Behav 20(4):602–606
Rahimi N, Sadeghzadeh M, Javadi-Paydar M, Heidary MR, Jazaeri F, Dehpour AR (2014) Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. Epilepsy Behav 39:42–47
Tsikas D (2007) Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research. J Chromatogr 851(1):51–70
Del Vecchio RA, Gold LH, Novick SJ, Wong G, Hyde LA (2004) Increased seizure threshold and severity in young transgenic CRND8 mice. Neurosci Lett 367(2):164–167
Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, Casamenti F (2015) Oleuropein aglycone protects against pyroglutamylated-3 amyloid-β toxicity: biochemical, epigenetic and functional correlates. Neurobiol Aging 36(2):648–663
Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR (2011) The neuroprotective effect of olive leaf extract is related to improved blood–brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine 18(2):170–175
Rauwald HW, Brehm O, Odenthal KP (1994) Screening of nine vasoactive medicinal plants for their possible calcium antagonistic activity. Strategy of selection and isolation for the active principles of Olea europaea and Peucedanum ostruthium. Phytother Res 8(3):135–140
Wang L, Geng C, Jiang L, Gong D, Liu D, Yoshimura H, Zhong L (2008) The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Euro J Nutr 47(5):235–243
Cullinen K (2006) Olive oil in the treatment of hypercholesterolemia. Med Health RI 89(3):113
Owen RW, Giacosa A, Hull WE, Haubner R, Würtele G, Spiegelhalder B, Bartsch H (2000) Olive-oil consumption and health: the possible role of antioxidants. Lancet Oncol 1(2):107–112
Ueda S, Tokuda H, Iwashima A, Nishino H (1994) Chemoprevention of skin and lung cancer by Gardenia iridoid. In: Proceedings International Congress on Natural Products Research
Nekooeian AA, Khalili A, Khosravi MB (2014) Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. J Asian Nat Prod Res 16(9):953–962
Sardo P, D’Agostino S, Rizzo V, Carletti F, Lonobile G, Ferraro G (2009) In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide-active drugs. J Neural Transm 116:831–839
Javadian N, Rahimi N, Javadi-Paydar M, Doustimotlagh A, Dehpour AR (2016) The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice. Epilepsy Res 126:134–140