石衫碱甲
品名:石衫碱甲
檢測方式: HPLC
規格:石衫碱甲1% 5% 98% HPLC
分子式: C15H18N2O
分子量: 242.316
CAS 號.: 120786-18-7
石杉碱甲，用於中、老年良性記憶障礙及各型癡呆、記憶認知功能及情緒行為障礙。尚可用於治療重症肌無力。
石衫碱甲的功效：
1.石杉碱能改善阿爾茨海默病、多發性心臟癡呆和老年癡呆患者的記憶、思維和行為功能，並通過阻斷其分解增加神經遞質乙酰膽碱的水平。
2。它還可以保護神經元免受谷氨酸中毒引起的細胞 ，並保護神經元免受戰爭中使用的化學神經制劑（如梭曼）的某些影響。
3.在一項隨機對照試驗中，它也是AD對認知功能影響的治療方法。
參考文獻：
- 1.
Bei D, Tang X, He X (2000) Curr Med Chem 7:355–374
- 2.
Howes MJ, Perry NS, Houghton PJ (2003) Phytother Res 17:1–18.
- 3.
Ye JW, Cai JX, Wang LM, Tang XC (1999) J Pharmacol Exp Ther 288:814–819
- 4.
Zangara A (2003) Pharmacol Biochem Behav 75:675–686.
- 5.
Lallement G, Baille V, Baubichon D, Carpentier P, Collombet JM, Filliat P, Foquin A, Four E, Masqueliez C, Testylier G, Tonduli L, Dorandeu F (2002) Neurotoxicology 23:1–5.
- 6.
Ye JC, Zeng S, Zhang WG, Chen GS (2005) J Chromatogr B Analyt Technol Biomed Life Sci 817:187–191.
- 7.
Qian BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS (1995) Zhongguo Yao Li Xue Bao 16:396–398
- 8.
Wei GL, Xiao SH, Lu R, Liu CX (2006) J Chromatogr B Analyt Technol Biomed Life Sci 830:120–125.
- 9.
Ye JC, Zeng S, Zhang GL, Chen GS (2008) Int J Pharm 356:187–192
- 10.
Yue P, Tao T, Zhao Y, Ren JF, Chai XY (2007) J Pharm Biomed Anal 44:309–312.
- 11.
Chu DF, Liu WH, Li YX, Li PF, Gu JK, Liu K (2006) Planta Med 72:552–555.
- 12.
Fu XD, Ping QN, Gao YL, Guo JF (2004) J China Pharm Univ 35:235–238
- 13.
Liu X, Li D, Wang XL, Chen CL (2006) Fudan Univ J Med Sci 33:247–250
- 14.
Li YX, Jiang XH, Lan K, Wang L (2007) Biomed Chromatogr 21:15–20.
- 15.
Li C, Du FF, Yu C, Xu X, Zheng J, Xu F, Zhu DY (2004) Rapid Commun Mass Spectrom 18:651–656.
- 16.
Wang YW, Chu DF, Gu JK, Fawcett JP, Wu Y, Liu WH (2004) J Chromatogr B Analyt Technol Biomed Life Sci 803:375–378.
- 17.
Li W, Li JH, Hu Q (2008) Biomed Chromatogr 22:354–360.
- 18.
Hameda AB, Taborsky P, Pena-Mendez EM, Havel J (2007) Talanta 72:780–784.
- 19.
Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2001