唾液酸,燕窩酸

品名:燕窩酸

其他名稱: N-Acetylneuraminic Acid, Neu5Ac, NANA Powder

CAS 號.:131-48-6

純度:98% min

分子量:309.2699

外觀:Whiter powder

唾液酸是9-碳單糖的衍生物,學名叫作“N-乙酰基神經氨酸”,是一種天然存在的碳水化合物。它最初由頜下腺粘蛋白中分離而出,也因此而得名。

唾液酸通常以低聚糖,糖脂或者糖蛋白的形式存在。人體中,腦的唾液酸含量 。腦灰質中的唾液酸含量是肝、肺等內臟 的15倍。唾液酸的主要食物來源是母乳,也存在於牛奶、雞蛋和奶酪中。

唾液酸可以阻止病菌入侵,唾液酸同時也是流感病毒的受體,是流感病毒結合在黏液細胞中的結合位點。

產品詳詢:13657416805

References:

  1. 1.
    Aula N, Salomaki P, Timonen R, Verheijen F, Mancini G, Mansson JE, Aula P, Peltonen L (2000) The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. Am J Hum Genet 67:832–840
  2. 2.
    Aula P, Autio S, Raivio KO, Rapola J, Thoden CJ, Koskela SL, Yamashina I (1979) “Salla disease”: a new lysosomal storage disorder. Arch Neurol 36:88–94
  3. 3.
    Aula P, Gahl WA (2001) Disorders of free sialic acid storage. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular Bases of Inherited Disease. New York, McGraw Hill, pp 5109–5120
  4. 4.
    Cardo PP, Lombardo C, Gatti R (1985) A simple detection of sialic acid storage disorders by urinary ‘free’ and ‘total’ sialic acid determinations. Clin Chim Acta 150:129–135
  5. 5.
    Denny PC, Denny PA, Allerton SE (1983) Determination of sialic acid using 2-thiobarbituric acid in the absence of hazardous sodium arsenite. Clin Chim Acta 131:333–336
  6. 6.
    Froissart R, Cheillan D, Bouvier R, Tourret S, Bonnet V, Piraud M, Maire I (2005) Clinical, morphological, and molecular aspects of sialic acid storage disease manifesting in utero. J Med Genet 42:829–836
  7. 7.
    Galjaard H (1980) Genetic Metabolic Diseases. Elsevier/North-Holland Biomedical, Amsterdam
  8. 8.
    Grosso S, Berardi R, Farnetani MA, Margollicci M, Mancini MG, Morgese G, Balestri P (2001) Multiple neuroendocrine disorder in Salla disease. J Child Neurol 16:775–777
  9. 9.
    Ito M, Ikeda K, Suzuki Y, Tanaka K, Saito M (2002) An improved fluorometric high-performance liquid chromatography method for sialic acid determination: an internal standard method and its application to sialic acid analysis of human apolipoprotein E. Anal Biochem 300:260–266
  10. 10.
    Krasnewich DM, Tietze F, Krause W, Pretzlaff R, Wenger DA, Diwadkar V, Gahl WA (1993) Clinical and biochemical studies in an American child with sialuria. Biochem Med Metab Biol 49:90–96
  11. 11.
    Mancini GM, Beerens CE, Aula PP, Verheijen FW (1991) Sialic acid storage diseases. A multiple lysosomal transport defect for acidic monosaccharides. J Clin Invest 87:1329–1335
  12. 12.
    Mancini GM, Hu P, Verheijen FW, van Diggelen OP, Janse HC, Kleijer WJ, Beemer FA, Jennekens FG (1992) Salla disease variant in a Dutch patient. Potential value of polymorphonuclear leucocytes for heterozygote detection. Eur J Pediatr 151:590–595
  13. 13.
    Powell LD, Hart GW (1986) Quantitation of picomole levels of N-acetyl- and N-glycolylneuraminic acids by a HPLC-adaptation of the thiobarbituric acid assay. Anal Biochem 157:179–185
  14. 14.
    Roboz J, Suttajit M, Bekesi JG (1981) Elimination of 2-deoxyribose interference in the thiobarbituric acid determination of N-acetylneuraminic acid in tumor cells by pH-dependent extraction with cyclohexanone. Anal Biochem 110:380–388
  15. 15.
    Seppala R, Lehto VP, Gahl WA (1999) Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme. Am J Hum Genet 64:1563–1569
  16. 16.
    Sewell AC, Poets CF, Degen I, Stoss H, Pontz BF (1996) The spectrum of free neuraminic acid storage disease in childhood: clinical, morphological and biochemical observations in three non-Finnish patients. Am J Med Genet 63:203–208
  17. 17.
    Schauer R (2000) Achievements and challenges of sialic acid research. Glycoconj J 17:485–499
  18. 18.
    Traving C, Schauer R (1998) Structure, function and metabolism of sialic acids. Cell Mol Life Sci 54:1330–1349
  19. 19.
    Valianpour F, Abeling NG, Duran M, Huijmans JG, Kulik W (2004) Quantification of free sialic acid in urine by HPLC-electrospray tandem mass spectrometry: a tool for the diagnosis of sialic acid storage disease. Clin Chem 50:403–409
  20. 20.
    Verheijen FW, Verbeek E, Aula N, Beerens CE, Havelaar AC, Joosse M, Peltonen L, Aula P, Galjaard H, van der Spek PJ, Mancini GM (1999) A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases. Nat Genet 23:462–465
  21. 21.
    Verheijen FW, Mancini GM (2003) Lysosomal sialic acid transporter sialin (SLC17A5):sialic acid storage disease (SASD). In: Broer S, Wagner CA (eds) Membrane Transporter Diseases. Kluwer Academic/Plenum, New York, pp 233–239
  22. 22.
    Warren L (1959) The thiobarbituric acid assay of sialic acids. J Biol Chem 234:1971–1975 </