白色針狀結晶或粒狀固體。呈覆盆子香氣和水果香甜味。熔點82～83℃。不溶于水和石油英，溶于乙醇、 和揮發性油。天然品存在於覆盆子(樹莓)等中。

 用途：用於調製食品香料，具有增香增甜作用，也可用於化妝品及皂用香精中，覆盆子提取物，中藥的一種。具有益腎，固精，縮尿的功效。

 

參考文獻：

 

1. 1. 

   Ogawa, Y., Akamatsu, M., Hotta, Y., Hosoda, A., Tamura, H.: Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Med. Chem. Lett. B 20, 2111–2114 (2010)

2. 2. 

   Kosjek, B., Stampfer, W., Deursen, R.V., Faber, K., Kroutil, W.: Efficient production of raspberry ketone via ‘green’ biocatalytic oxidation. Tetrahedron 59, 9517–9521 (2003)

3. 3. 

   Harada, N., Okajima, K., Narimatsu, N., Kurihara, H., Nakagata, N.: Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res. 18, 335–344 (2008) 

4. 4. 

   Larsen, M., Poll, L.: Odour thresholds of some important aroma compounds in raspberries. Z. Lebensm Unters Forsch. 191, 129–131 (1990)

5. 5. 

   Bredsdorff, L., Wedebye, E.B., Nikolov, N.G., Hallas-Møller, T., Pilegaard, K.: Raspberry ketone in food supplements – High intake, few toxicity data – a cause for safety concern? Regul. Toxicol. Pharm. 73, 196–200 (2015)

6. 6. 

   Hoelderich, W.F., Ritzerfeld, V.: Preparation of a raspberry ketone precursor in the presence of rare earth oxide catalysts. Appl. Catal. A: General 504, 654–663 (2015) 

7. 7. 

   Shimoda, K., Harada, T., Hamada, H., Nakajima, N., Hamada, H.: Biotransformation of raspberry ketone and zingerone by cultured cells of Phytolacca americana. Phytochemistry. 68, 487–492 (2007)

8. 8. 

   Takiyama, H.: Supersaturation operation for quality control of crystalline particles in solution crystallization. Adv. Powder Technol. 23, 273–278 (2012)

9. 9. 

   Parimaladevi, P., Srinivasan, K.: Influence of supersaturation level on the morphology of a-lactose monohydrate crystals. Int. Dairy J. 39, 301–311 (2014)

10. 10. 

    Jiang, L.K., Wang, L.S., Du, C.J., Sun, G.Q., Qi, C.M.: Measurement and correlation of the solubilities of tetra(5,5-dimethyl-1,3-dioxaphosphorinanyl-2-oxy) neopentane in different pure solvents. Fluid Phase Equilib. 367, 117–124 (2014)

11. 11. 

    Matsuda, H., Mori, K., Tomioka, M., Kariyasu, N., Fukami, T., Kurihara, K., Tochigi, K., Tomono, K.: Determination and prediction of solubilities of active pharmaceutical ingredients in selected organic solvents. Fluid Phase Equilib. 406, 116–123 (2015)

12. 12. 

    Liu, Z.K., Yin, Q.X., Zhang, X.W., Zhang, H., Gong, J.B., Wang, J.K.: Measurement and correlation of the solubility of 4,4-oxydianiline in different organic solvents. Fluid Phase Equilib. 356, 38–45 (2013)

13. 13. 

    Zhu, L., Wang, L.Y., Li, X.C., Sha, Z.L., Wang, Y.F., Yang, L.B.: Experimental determination and correlation of the solubility of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (DMHF) in six different solvents. J. Chem. Thermodyn. 91, 369–377 (2015)

14. 14. 

    Xiao, L.P., Wang, Y.L., Yang, J.X., Yuan, F.H., Jiang, C., Hou, B.H., Xie, C.: Determination and correlation of solubility of 4′-bromomethyl-2-cyanobiphenyl in acetone + (ethanol, n-propanol, n-butanol) mixtures. J. Chem. Thermodyn. 102, 199–210 (2016)

15. 15. 

    Apelblat, A., Manzurola, E.: Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic, and p-toluic acid, and magnesium-DL-aspartate in water from T = (278 to 348) K. J. Chem. Thermodyn. 31, 85–91 (1999) 

16. 16. 

    Kai, Y.M., Hu, Y.H., Liu, Y., Liang, M.M., Yang, W.G., Xi, Y.: The solubility of mercaptosuccinic acid in water + (methanol, ethanol, acetone) mixtures from (278.15 to 333.15 K). Fluid Phase Equilib. 361, 282–288 (2014) 

17. 17. 

    Wang, G., Wang, Y.L., Ma, Y.G., Hao, H.X., Luan, Q.H., Wang, H.H.: Determination and correlation of cefuroxime acid solubility in (acetonitrile + water) mixtures. J. Chem. Thermodyn. 77, 144–150 (2014)

18. 18. 

    Sunsandee, N., Hronec, M., Štolcová, M., Leepipatpiboon, N., Pancharoen, U.: Thermodynamics of the solubility of 4-acetylbenzoic acid in different solvents from 303.15 to 473.15 K. J. Mol. Liq. 180, 252–259 (2013) 

19. 19. 

    Buchowski, H., Ksiazczak, A., Pietrzyk, S.: Solvent activity along a saturation line and solubility of hydrogen-bonding solids. J. Phys. Chem. 84, 975–979 (1980)

20. 20. 

    Soltanpour, S., Gharagozlu, A.: Piroxicam Solubility in binary and ternary solvents of polyethylene glycols 200 or 400 with ethanol and water at 298.2 K: experimental data report and modeling. J. Solution Chem. 44, 1407–1423 (2015)

21. 21. 

    Morimoto, C., Satoh, Y., Hara, M., Inoue, S., Tsujita, T., Okuda, H.: Anti-obese action of raspberry ketone. Life Sci. 77, 194–204 (2005)

22. 22. 

    Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., Yazaki, K.: Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem. Biophys. Res. Commun. 412, 104–108 (2011)

23. 23. 

    Meng, Z.B., Hu, Y.H., Kai, Y.M., Yang, W.G., Cao, Z., Shen, F.: Thermodynamics of solubility of thiomalic acid in different organic solvents from 278.15 K to 333.15 K. Fluid Phase Equilib. 352, 1–6 (2013)

24. 24. 

    Moodley, K., Rarey, J., Ramjugernath, D.: Experimental solubility for betulin and estrone in various solvents within the temperature range T = (293.2 to 328.2) K. J. Chem. Thermodyn. 98, 42–50 (2016)

25. 25. 

    Ha, E.S., Kim, J.S., Kuk, D.H., Ha, D.H., Baek, I.H., Kim, M.S.: Determination and correlation of solubility of Pranlukast hemihydrate in five organic solvents at different temperatures and its dissolution properties. J. Mol. Liq. 225, 231–234 (2017)

26. 26. 

    Pawar, R.R., Aher, C.S., Pagar, J.D., Nikam, S.L., Hasan, M.: Solubility, density and solution thermodynamics of NaI in different pure solvents and binary mixtures. J. Chem. Eng. Data 57, 3563–3572 (2012)

27. 27. 

    Tao, M.Y., Sun, H., Wang, Z., Cui, P.L., Wang, J.K.: Correlation of solubility of pioglitazone hydrochloride in different binary solvents. Fluid Phase Equilib. 352, 14–21 (2013)