厚朴提取物

 

來源: 厚朴

拉丁名稱:Magnolia officinalis.

提取部位: 為木蘭科落葉喬木植物厚朴Magnolia officinalis Rehd.et Wils.或凹葉厚朴M.officinalis Rehd.et Wils. var.biloba Rehd.et Wils.的干皮、根皮及枝皮

規格: 1%-98%
有效成份 :厚朴酚,和厚朴酚,厚朴總酚

CAS:magnolol:528-43-8,honokiol:35354-74-6,

magnolol+honokiol:1445684-99-0

檢測方式:HPLC
顏色: 淺黃色至類白色

 

厚朴,為木蘭科植物厚朴和廬山厚朴的樹皮、根皮和枝皮。厚朴提取物的主要成分有厚朴酚、和厚朴酚,厚朴油揮發油的主要成分為桉葉油醇,厚朴提取物中的生物碱有厚朴碱。目前主要提取的有效成分有,厚朴總酚,厚朴酚和和厚朴酚,同時厚朴也常用在化妝品中作為廣譜抗菌素,抗菌美白和天然防腐劑。

 

厚朴別名香朴、赤朴、紫油厚朴等,為常用中藥。首載于《神農本草經》,列為中品。 厚朴提取物是以厚朴 Magnolia officinalis 等的乾燥的根皮、莖皮或枝皮為原料提取的 產品,商品提取物通常對厚朴酚、和厚朴酚的含量進行標化。
 
【分布】木蘭科木蘭屬植物全世界約有 90 種,我國約有 30 種,其中有藥用價值的約 20 種。厚朴生于海拔 300
1700m 的土壤肥沃、土深厚的向陽山坡、林緣處。
 
【產地】厚朴主要分布于湖北西部、四川南部、陝西南部及甘肅南部;凹葉厚朴主要分 布于江西、安徽、浙江、福建、湖南、廣西及廣東北部。厚朴、凹葉厚朴多有交叉分布,均 有大麵積人工栽培。
 
【主要成分】厚朴樹皮含厚朴酚、和厚朴酚、異厚朴酚等成分。並從厚朴的乙酸乙酯提 取液中分離出了三羥基厚朴酚,去氧三羥基厚朴酚,三羥基厚朴醛,聚厚朴酚甲、丙。樹皮 含揮發油約 1%,油中主要含β - 油醇; 尚含α - 蒎烯、β
- 蒎烯、檸檬烯、乙酸龍腦酯。樹 皮中亦含木蘭箭毒碱。葉亦含厚朴酚、和厚朴酚。
 
【采收加工】4 6 月剝取生長 15 年以上樹的干皮,置沸水中微煮后,堆置土坑里,上 蓋青草使之 發汗 ,待水分自內部滲出后,內表面變紫褐色或棕褐色時,再蒸軟,取出, 捲成筒狀,曬乾或炕干。根皮及枝皮剝下后可直接陰乾。

厚朴提取物的應用

醫藥

日化用品

護膚品

厚朴提取物的含量測定

【含量測定】照高效液相色譜法測定。

色譜條件與系統使用性試驗 以十八烷基硅烷鍵合硅膠為填充劑,以甲醇、水(78:22)
為流動相;檢測波長為 294nm.理論板數按照厚朴酚計算應不低於 3800.
 
對照品溶液的制備
取厚朴酚對照品、和厚朴酚對照品適量,精密稱定,加甲醇分別製成每 1ml 含厚朴酚
45ug、和厚朴酚 45ug 的溶液,即得。
 
供試品溶液的制備
取樣品適量,精密稱定,置容量瓶中,加甲醇 - 水(78:22)溶解,精密加入甲醇、水(78:22)
至刻度線,密塞,搖勻,濾過,即得。
測定法 分別精密吸取上述兩種對照品溶液各 10ul 與供試品溶液 10ul,注入液相色譜 儀,測定,即得。
 
物理性質
本品為棕褐色至白色精細粉末,氣香,味辛辣,微苦。單體為無色鱗片狀晶體。熔點
87.5℃。旋光度±0°, cm  1:3280,1610,1500,882,826。可溶于 般的有機溶劑,易溶
于苯, ,氯仿,乙醇等,難溶于水。在氯仿中與氯化鐵作用成藍色。與三氯化鐵甲醇溶
液反應,顯藍黑色,與 Millon 試劑反應,現棕色沉澱,與間苯三酚鹽酸溶液反應現紅色沉

 

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Helicobacter pylori (H. pylori) infection is now established as the major pathogenic factor in chronic gastritis and peptic ulcer disease. In addition, there is accumulating evidence that

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Hee Wook Park, Jae Hyeok Lee, Sang-Un Choi, Nam-In Baek… in Archives of Pharmacal Research (2010)

21.Effects of (+)-eudesmin from the stem bark of Magnolia kobus DC. var.borealis Sarg. on neurite outgrowth in PC12 cells
(+)-Eudesmin [4,8-bis (3,4-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane] was isolated from the stem bark ofMagnolia kobus DC. var.borealis Sarg. and found to have neuritogenic activity. 50 μM (+)-eudesmin induc...

Yoo Jung Yang, Jae In Park, Hak-Ju Lee, Seon-Mi Seo… in Archives of Pharmacal Research (2006)

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A new furofuran lignan (1) along with four knownones (2-5) were isolated from the bark of Magnolia kobus. Their structures were elucidated as (+)-2α-(3’,4’-dimethoxyphenyl)-6α-(3″-hydroxy-4″,5″-dimethoxyphenyl)-3...

Seon-Mi Seo, Hak-Ju Lee, Oh-Kyu Lee, Hyun-Jin Jo… in Chemistry of Natural Compounds (2008)

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In a course of obtaining more amount of bioactive costunolide and successive phytochemical isolation fromMagnolia sieboldii (Magnoliaceae), a novel acyclic monoterpene 1 named deoxygeraniol (2,6(E)-dimethyl-2, 6-...

Hee Juhn Park, Sang Hyuk Kwon, Yong Nam Han… in Archives of Pharmacal Research (2001)

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name “Houpo”, has been traditionally us...

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Magnolol, honokiol, and obovatol are well-known bioactive constituents of the bark of Magnolia officinalis and have been used as traditional Chinese medicines for the treatment of neurosis, anxiety, and stroke. W...

Yong Kyung Lee, Dong Yeon Yuk, Tae Il Kim, Young Heui Kim… in Journal of Natural Medicines (2009)

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Li-Hong Tan, Dan Zhang, Bao Yu, Sheng-Ping Zhao… in European Food Research and Technology (2015)

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Hyungeun Yoon in Food Science and Biotechnology (2014)

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Shawn M Talbott, Julie A Talbott, Mike Pugh in Journal of the International Society of Sp… (2013)

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