石杉碱甲huperzine a

石衫碱甲

品名:石衫碱甲

检测方式: HPLC

规格:石衫碱甲1% 5% 98% HPLC

分子式: C15H18N2O

分子量: 242.316

CAS 号.: 120786-18-7

石杉碱甲，用于中、老年良性记忆障碍及各型痴呆、记忆认知功能及情绪行为障碍。尚可用于治疗重症肌无力。

石衫碱甲的功效：

1.石杉碱能改善阿尔茨海默病、多发性心脏痴呆和老年痴呆患者的记忆、思维和行为功能，并通过阻断其分解增加神经递质乙酰胆碱的水平。

2。它还可以保护神经元免受谷氨酸中毒引起的细胞，并保护神经元免受战争中使用的化学神经制剂（如梭曼）的某些影响。

3.在一项随机对照试验中，它也是AD对认知功能影响的治疗方法。

参考文献：

1.
Bei D, Tang X, He X (2000) Curr Med Chem 7:355–374
2.
Howes MJ, Perry NS, Houghton PJ (2003) Phytother Res 17:1–18.
3.
Ye JW, Cai JX, Wang LM, Tang XC (1999) J Pharmacol Exp Ther 288:814–819
4.
Zangara A (2003) Pharmacol Biochem Behav 75:675–686.
5.
Lallement G, Baille V, Baubichon D, Carpentier P, Collombet JM, Filliat P, Foquin A, Four E, Masqueliez C, Testylier G, Tonduli L, Dorandeu F (2002) Neurotoxicology 23:1–5.
6.
Ye JC, Zeng S, Zhang WG, Chen GS (2005) J Chromatogr B Analyt Technol Biomed Life Sci 817:187–191.
7.
Qian BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS (1995) Zhongguo Yao Li Xue Bao 16:396–398
8.
Wei GL, Xiao SH, Lu R, Liu CX (2006) J Chromatogr B Analyt Technol Biomed Life Sci 830:120–125.
9.
Ye JC, Zeng S, Zhang GL, Chen GS (2008) Int J Pharm 356:187–192
10.
Yue P, Tao T, Zhao Y, Ren JF, Chai XY (2007) J Pharm Biomed Anal 44:309–312.
11.
Chu DF, Liu WH, Li YX, Li PF, Gu JK, Liu K (2006) Planta Med 72:552–555.
12.
Fu XD, Ping QN, Gao YL, Guo JF (2004) J China Pharm Univ 35:235–238
13.
Liu X, Li D, Wang XL, Chen CL (2006) Fudan Univ J Med Sci 33:247–250
14.
Li YX, Jiang XH, Lan K, Wang L (2007) Biomed Chromatogr 21:15–20.
15.
Li C, Du FF, Yu C, Xu X, Zheng J, Xu F, Zhu DY (2004) Rapid Commun Mass Spectrom 18:651–656.
16.
Wang YW, Chu DF, Gu JK, Fawcett JP, Wu Y, Liu WH (2004) J Chromatogr B Analyt Technol Biomed Life Sci 803:375–378.
17.
Li W, Li JH, Hu Q (2008) Biomed Chromatogr 22:354–360.
18.
Hameda AB, Taborsky P, Pena-Mendez EM, Havel J (2007) Talanta 72:780–784.
19.
Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2001