虫草素又称冬虫夏草素、虫草菌素、蛹虫草菌素，别名3′－脱氧腺苷，是 个从真菌中分离出来的核苷类抗生素。

 目前研究结果表明，虫草素具有肺肾的保护性、抗三高、抗肿瘤、神经保护性、抗炎、抗氧化和免疫调节等生物活性。因此，虫草素在抗衰老、保健、新药研制等领域备受学者关注

理化性质：

虫草素的分子式为C10H13N5O3，相对分子质量为251.25，能溶于水，乙醇，虫草素为含氮配糖体的核酸衔生物,属嘌呤类生物碱；

虫草素化学性质：

熔点：225-229°C

比旋光度: D20 -47°; D27 -42°

沸点:394.4°C

密度：1.2938

折射率：1.7610

储存条件：−20°C

 

产品详询:13657416805

References:

 

1. 1.

   Cui, J. D. (2015) Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine. Critical Rev. Biotechnol. 35: 475–484.

    

2. 2.

   Fung, J., G. Yue, K. P. Fung, X. Ma, X. Q. Yao, and W. H. Ko (2011) Cordyceps militaris extract stimulates Cl(-) secretion across human bronchial epithelia by both Ca(2+)(-) and cAMPdependent pathways. J. Ethnopharmacol. 138: 201–211

3. 3.

   Tuli, H., S. Sandhu, and A. Sharma (2013) Pharmacological and therapeutic potential of Cordyceps with special reference to cordycepin. 3 Biotech. 4: 1–12.

4. 4.

   Ueda, Y., K. Mori, S. Satoh, H. Dansako, M. Ikeda, and N. Kato (2014) Anti-HCV activity of the Chinese medicinal fungus Cordyceps militaris. Biochem. Biophys. Res. Commun. 447: 341–345.

5. 5.

   Wasser, S. (2014) Medicinal mushroom science: Current perspective, advances, evidences and challenges. Biomed. J. 37: 345–356.

6. 6.

   Lennon, M. B. and R. J. Suhadolnik (1976) Biosynthesis of 3’-deoxyadenosine by Cordyceps militaris. Mechanism of reduction. Biochim. Biophysic. Acta 425: 532–536.

7. 7.

   Xiang, L., Y. Li, Y. Zhu, H. Luo, C. Li, X. Xu, C. Sun, J. Song, L. Shi, L. He, W. Sun, and S. Chen (2014) Transcriptome analysis of the Ophiocordyceps sinensis fruiting body reveals putative genes involved in fruiting body development and cordycepin biosynthesis. Genom. 103: 154–159

8. 8.

   Yin, Y., G. Yu, Y. Chen, S. Jiang, M. Wang, Y. Jin, X. Lan, Y. Liang, and H. Sun (2012) Genome-wide transcriptome and proteome analysis on different developmental stages of Cordyceps militaris. PLoS One 7: 51853.

9. 9.

   Zheng, P., Y. Xia, G. Xiao, C. Xiong, X. Hu, S. Zhang, H. Zheng, Y. Huang, Y. Zhou, S. Wang, G. P. Zhao, X. Liu, R. J. St. Leger, and C. Wang (2011) Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine. Genome Biol. 12: R116.

10. 10.

    Ni, H., X.H. Zhou, H. H. Li, and W. F. Huang (2009) Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium. J. Chromatogr. B 877: 2135–2141.

11. 11.

    Rottman, F., M. L. Ibershof, and A. J. Guarino (1963) Studies on the synthesis and structure of cordycepin monophosphate. Biochim. Biophysic. Acta 76: 181–187.

12. 12.

    Wang, H., M. Pan, C. Chang, S. Chang, and W. Hseih (2014) Optimization of ultrasonic-assisted extraction of cordycepin from Cordyceps militaris using orthogonal experimental design. Molecules 199: 20808–20820.

13. 13.

    Zhou, X., Z. Gong, Y. Su, J. Lin, and K. Tang (2009) Cordyceps fungi: Natural products pharmacological functions and developmental products. J. Pharm. Pharmacol. 61: 279–291.

14. 14.

    Das, S. K., M. Masuda, M. Hatashita, A. Sakurai, and M. Sakakibara (2010) Optimization of culture medium for cordycepin production using Cordyceps militaris mutant obtained by ion beam irradiation. Proc. Biochem. 45: 129–132.

15. 15.

    Masuda, M., E. Urabe, H. Honda, A. Sakurai, and M. Sakakibara (2007) Enhanced production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris. Enz. Microb. Technol. 40: 1199–1205.

16. 16.

    Das, S. K., M. Masuda, M. Hatashita, A. Sakurai, and M. Sakakibara (2008) A new approach for improving cordycepin productivity in surface liquid culture of Cordyceps militaris using high energy ion beam irradiation. Lett. Appl Microbiol. 47: 534–538.

17. 17.

    Tang, Y. J. and J. J. Zhong (2003) Scale-up of a liquid surface culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnol. Prog. 19: 1842–1846.

18. 18.

    Kang, C., T. C. Wen, J. C. Kang, Z. B. Meng, G. R. Li, and K. D. Hyde (2014) Optimization of large-scale culture conditions for the production of cordycepin with Cordyceps militaris by liquid surface culture. The Scientific World J. 2014: 510627.

19. 19.

    Mao, X. B. and J. J. Zhong (2004) Hyperproduction of cordycepin by two-stage dissolved oxygen control in submerged cultivation of medicinal mushroom Cordyceps militaris in bioreactors. Biotechnol. Prog. 20: 1408–1413.

20. 20.

    Dong, J. Z., M. R. Lui, C. Lei, X. J. Zheng, and Y. Wang (2012) Effects of selenium and light wavelengths on liquid culture of Cordyceps militaris link. Appl. Biochem. Biotechnol. 166: 2030–2036.

21. 21.

    López, F. N., M. C. Quintana, and A. G. Fernández (2006) The use of a D-optimal design to model the effects of temperature, NaCl, type and acid concentration on Lactobacillus pentosus IGLAC01. J. Appl. Microbiol. 101: 913–926.

22. 22.

    Piccolomini, A. A., A. Fiabon, M. Borrotti, and D. De Lucrezia (2016) Optimization of thermophilic trans-isoprenyl diphosphate synthase expression in Escherichia coli by response surface methodology. Biotechnol. Appl. Biochem. DOI: 10.1002/bab.1459

23. 23.

    Srikanth, R., G. Siddartha, C. H. Sundhar Reddy, B. S. Harish, R. M. Janaki, and K. B. Ramaiah (2015) Antioxidant and antiinflammatory levan produced from Acetobactor xylinum NCIM2526 and its statistical optimization. Carbohyd. Polym. 123: 8–16.

24. 24.

    Zhou, Q., J. Su, H. Jiang, X. Huang, and Y. Xu (2010) Optimization of phenazine-1-carboxylic acid production by a gacA/ qscR-inactivated Pseudomonas sp. M18GQ harboring pME6032Phz using response surface methodology. Appl. Microbiol. Biotechnol. 86: 1761–1773.

25. 25.

    Zheng, Z. L., X. H. Qiu, and R. C. Han (2015) Identification of the genes involved in the fruiting body production and cordycepin formation of Cordyceps militaris fungus. Mycobiol. 43: 37–42.

26. 26.

    Das, S. K., M. Masuda, A. Sakurai, and M. Sakakibara (2009) Effects of additives on Cordycepin production using a Cordyceps militaris mutant induced by ion beam irradiation. Afr. J. Biotechnol. 8: 3041–3047.

27. 27.

    Mao, X. B., T. Eksriwong, S. Chauvatcharin, and J. J. Zhong (2005) Optimization of carbon source and carbon/nitrogen ratio for cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris. Proc. Biochem. 40: 1667–1672.

28. 28.

    Mao, X. B. and J. J. Zhong (2006) Significant effect of NH4 + on cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris. Enz. Microb. Technol. 38: 343–350.

29. 29.

    Shih, I. L., K. L. Tsai, and C. Hsieh (2007) Effects of culture conditions on the mycelial growth and bioactive metabolite production in submerged culture of Cordyceps militaris. Biochem. Eng. J. 33: 193–201.

30. 30.

    Masuda, M., E. Urabe, A. Sakurai, and M. Sakakibara (2006) Production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris. Enz. Microb. Technol. 40: 1199–1205.

31. 31.

    Masuda, M., S. K. Das, S. Fujihara, M. Hatashita, and A. Sakurai (2014) Efficient production of cordycepin by the Cordyceps militaris mutant G81-3 for practical use. Proc. Biochem. 49: 181–187

32.