【产品名称】 石榴皮提取物鞣花酸

【英文名称】 Pomegranate P.E.

【分析指标】 鞣花酸

【药用部位】 果皮

【外 观】 灰色粉末

【含 量】 鞣花酸40%

【检测方法】 HPLC

【产品来源】 为石榴科植物石榴的干燥果皮。

【药理作用】 防治结肠癌，食管癌、肝癌、肺癌、及舌和皮肤肿瘤等病症;可增强人体免疫功能;有降压、镇静功效。用于医药及化妆品，作抗氧剂，具有 及抑制病毒作用。

1. 作用，鞣花酸可以抑制致癌剂的代谢活性，解除致癌物的毒性等。

2. 对人体免疫缺陷病毒的抑制作用

3. 抗氧化作用

4. 增白作用

5.降压、镇静作用

产品详询：13657416805

参考文献：

 

1. 1.

   De Pauw-Gillet MC, Houssier C, Fredericq E (1979) Interaction of DNA and purine nucleosides with cis-dichlorodiammineplatinum(II) and antimitotic activity of the complexes on meristematic root cells. Chem Biol Interact 25:87–102

2. 2.

   Güneri EA, Serbetçiogllu B, Ikiz AO, Güneri A, Ceryan K (2001) TEOAE monitoring of cisplatin induced ototoxicity in guinea pigs: the protective effect of vitamin B treatment. Auris Nasus Larynx 28:9–14

3. 3.

   Nagy JL, Adelstein DJ, Newman CW, Rybicki LA, Rice TW, Lavertu P (1999) Cisplatin ototoxicity: the importance of baseline audiometry. Am J Clin Oncol 28:305–308

4. 4.

   Rybak LP, Mukherjea D, Jajoo S, Ramkumar V (2009) Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med 219(3):177–186

5. 5.

   Laurell G, Bagger-Sjoback D (1991) Dose-dependent inner ear changes after i.v. administration of cisplatin. J Otolaryngol 20:158–167

6. 6.

   de Freitas MR, de Castro Brito GA, de Carvalho JV Jr, Gomes RM Jr, Barreto Martins MJ, de Albuquerque Ribeiro R (2009) Light microscopy study of cisplatin-induced ototoxicity in rats. J Laryngol Otol 123(6):590–597

7. 7.

   Lopez-Gonzalez MA, Guerrero JM, Rojas F, Delgado F (2000) Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants. J Pineal Res 28(2):73–80

8. 8.

   Daldal A, Odabasi O, Serbetcioglu B (2007) The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs. Otolaryngol Head Neck Surg 137(5):747–752

9. 9.

   Kalkanis JG, Whitworth C, Rybak LP (2004) Vitamin E reduces cisplatin ototoxicity. Laryngoscope 114(3):538–542

10. 10.

    Kasse CA, Cruz OL, Iha LC, Costa HO, Lopes EC, Coelho F (2008) The use of Maytenus ilicifolia to prevent cisplatin-induced ototoxicity. Braz J Otorhinolaryngol 74(5):712–717

11. 11.

    Feghali JG, Liu W, Van De Water TR (2001) L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity. Laryngoscope 111(7):1147–1155 

12. 12.

    Lynch ED, Gu R, Pierce C, Kil J (2005) Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen. Hear Res 201(1–2):81–89

13. 13.

    Campbell KC, Meech RP, Rybak LP, Hughes LF (1999) D-Methionine protects against cisplatin damage to the stria vascularis. Hear Res 138(1–2):13–28

14. 14.

    Kelly TC, Whitworth CA, Husain K, Rybak LP (2003) Aminoguanidine reduces cisplatin ototoxicity. Hear Res 186(1–2):10–16

15. 15.

    Fetoni AR, Quaranta N, Marchese R, Cadoni G, Paludetti G, Sergi B (2004) The protective role of tiopronin in cisplatin ototoxicity in Wistar rats. Int J Audiol 43(8):465–470

16. 16.

    Huang X, Whitworth CA, Rybak LP (2007) Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats. Otol Neurotol 28(6):828–833

17. 17.

    Teranishi MA, Nakashima T (2003) Effects of trolox, locally applied on round windows, on cisplatin-induced ototoxicity in guinea pigs. Int J Pediatr Otorhinolaryngol 67(2):133–139

18. 18.

    Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA 102(41):14813–14818

19. 19.

    Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L (2006) Cholesterol-lowering effect of concentrated pomegranate extract consumption in typeII diabetic patients with hyperlipidemia. Int J Vitam Nutr Res 76:147–151

20. 20.

    de Nigris F, Williams-Ignarro S, Sica V et al (2007) Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res 73:414–423

21. 21.

    Tugcu V, Kemahli E, Ozbek E et al (2008) Protective effect of a potent antioxidant, pomegranate extract, in the kidney of rats with nephrolithiasis induced by ethylene glycol. J Endourol 22:2723–2731

22. 22.

    Aviram M, Dornfeld L (2001) Pomegranate extract consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158:195–198

23. 23.

    Aviram M, Dornfeld L, Kaplan M et al (2002) Pomegranate extract flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res 28:49–62

24. 24.

    Cardinaal RM, Groot JCMJ, Huizing EH, Veldman JE, Smmorenbrg GF (2000) Dose-depend effect of 8-day ciplatin administration upon the morphology of the albino guinea pig cochlea. Hear Res 144:135–146

25. 25.

    Rybak LP, Whitworth MA, Somani S (1999) Application of antioxidants and other agents to prevent ciplatin ototoxicity. Laryngoscope 109:1740–1744

26. 26.

    Tzulker R, Glazer I, Bar-Ilan I, Holland D, Aviram M, Amir R (2007) Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions. J Agric Food Chem 55:9559–9570

27. 27.

    Viuda-Martos M, Ruiz-Navajas Y, Fernandez-Lopez J, Sendra E, Sayas-Barbera E, Perez-Alvarez JA (2010) Antioxidant properties of pomegranate (Punica granatum L.) bagasses obtained as co-product in the juice extraction. Food Res Int. 

28. 28.

    Poyrazoglu E, Gökmen V, Artik N (2002) Organic acids and phenolic compounds in pomegranates (Punica granatum L.) grown in Turkey. J Food Compos Anal 15:567–575

29. 29.

    Fischer UA, Carle R, Kammerer DR (2011) Identification and quantification of phenolic compounds from pomegranates (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MSn. Food Chem 127:807–821

30. 30.

    Clerici WJ, DiMartino DL, Prasad MR (1995) Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro. Hear Res 84:30–40

31. 31.

    Rybak LP (2007) Mechanisms of cisplatin ototoxicity and progress in otoprotection. Curr Opin Otolaryngol Head Neck Surg 15:364–369

32. 32.

    De Vita VT Jr (1997) Principles of cancer management: chemotherapy. In: De Vita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, pp 333–347

33. 33.

    Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V (2007) Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res 226(1–2):157–167