辛弗林synephrine

产地生源： 野生于四川、江西、浙江等地

检测方法： HPLC

辛弗林上禾生物synephrine

植物拉丁名： Fructus Aurantii Immaturus

提取物来源： 枳实

植物来源 ：芸香科植物酸橙(Citrus aurantium L.)的干燥幼果。 常绿小乔木，柑果圆形，略扁，橙黄色，果皮粗糙，花期4~5月，果期11月。

有效成分：辛弗林 -p，辛弗林-m

CAS：94-07-5

英文名称：synephrine

【熔点及溶解度】：游离的辛弗林熔点184-185，易溶于有机溶剂，难溶于水，其酸式盐和碱式盐则易溶于水，难溶于有机溶剂，盐酸盐结晶熔点151～152，易溶于水;重酒石酸盐熔点188～189，易溶于水，难溶于乙醇，几乎不溶于氯仿、 。

辛弗林是枳实提取物中的主要活性成分 辛弗林提取物Synephrine 上禾生物，其可有效预防能量过剩(热量堆积)，逐风理气，温胃促进食欲并加速新陈代谢。酸橙理论上可加速脂肪代谢且不会像使用麻黄的患者那样出现不良的副作用影响心血管。其也是一种温和的芬芳除痰剂，一种神经镇定剂和治疗便秘的轻泻剂。

可逆性胆碱酯酶(ACHE)抑制剂。治疗重症肌无力的作用与新斯的明相追认，维持时间明显长于新斯的明，毒性低，不良反应少，对乙酰胆碱醋本科具有选择性抑制作用，易通过血、脑脊液屏障。本品适用于良性记忆障碍，可显著改善AD患者认知功能、行为和心境障碍。对痴呆患者和脑器质 引起的记忆障碍亦有改善作用。

 

 产品详询：13657416805

参考文献:

 

1. 1.

   Viana RB, Naves JPA, Coswig VS et al (2019) Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT). Br J Sports Med.

2. 2.

   Donnelly JE, Blair SN, Jakicic JM et al (2009) Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sport Exerc 41:459–471.

3. 3.

   Bouchonville M, Armamento-Villareal R, Shah K et al (2014) Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial. Int J Obes 38:423–431. 

4. 4.

   Kim J-H, Park Y (2016) Combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutr Biochem 20:20–26. 

5. 5.

   Türközü D, Tek NA (2017) A minireview of effects of green tea on energy expenditure. Crit Rev Food Sci Nutr 57:254–258.  

6. 6.

   Gutiérrez-Hellín J, Del Coso J (2018) Effects of p-synephrine and caffeine ingestion on substrate oxidation during exercise. Med Sci Sports Exerc. 

7. 7.

   Stohs SJ, Preuss HG, Shara M (2012) A review of the human clinical studies involving Citrus aurantium (Bitter Orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci 9:527–538. 

8. 8.

   Allison DB, Cutter G, Poehlman ET et al (2005) Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain? Int J Obes 29:443–446. 

9. 9.

   Stohs SJ (2017) Safety, efficacy, and mechanistic studies regarding Citrus aurantium (Bitter Orange) extract and p-synephrine. Phyther Res 31:1463–1474. 

10. 10.

    Gutiérrez-Hellín J, Del Coso J (2018) Dose-response effects of p-synephrine on fat oxidation rate during exercise of increasing intensity. Phyther Res. 

11. 11.

    Gutiérrez-Hellín J, Del Coso J (2016) Acute p-synephrine ingestion increases fat oxidation rate during exercise. Br J Clin Pharmacol 82:362–368. 

12. 12.

    Edvardsen E, Hem E, Anderssen SA (2014) End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study. PLoS One 9:e85276. 

13. 13.

    Shara M, Stohs SJ, Smadi MM (2018) Safety evaluation of p-synephrine following 15 days of oral administration to healthy subjects: a clinical study. Phyther Res 32:125–131. 

14. 14.

    Ratamess NA, Bush JA, Kang J et al (2016) The effects of supplementation with p-synephrine alone and in combination with caffeine on metabolic, lipolytic, and cardiovascular responses during resistance exercise. J Am Coll Nutr 35:657–669.

15. 15.

    Stohs SJ, Preuss HG, Shara M (2011) A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxid Med Cell Longev 2011:482973.