Product Name: Magnolia Bark Extract

Latin Name: Mangnolia officinalis L. 

Active ingredients: honokiol


CAS NO.:35354-74-6

Test method:HPLC

According to E Natural Health Center, magnolia bark can help remove dampness from your body, relieve asthma and improve your digestion. Herbalists commonly prescribe magnolia bark for abdominal pain and distention, constipation, coughing and shortness of breath. Magnolia bark may also help relieve chest tightness and phlegm congestion that is associated with asthma. Herb Wisdom states that this herb can also help improve menstrual cramps, gas, nausea and indigestion.

 Two chemicals found in magnolia bark are honokiol and magnolol, which both have strong antioxidant activity. these two substances may help reduce stress and balance your cortisol levels. Therefore, magnolia may also help combat the effects of excessive stress.


Magnolia bark extract




Test Method






light yellow to white                  powder

   Soluble in        Organic      solvents





light yellow to white     powder




light yellow to white     powder

Magnolia oil



Brown liquid



 Staherb Honokiol Main Function:

(1). With the significant effect on muscle pain and in dental care; 
(2). With the significant effect on abdominal distension, diarrhea and other digestive problems and, respiratory problems;
(3).With good function of anti-anxiety;
(4).With the function of antibacterial, it has significant therapeutic efficacy on acute enteritis, bacterial or amoebic dysentery, chronic gastritis and other diseases.


Staherb Honokiol Application:

 (1). As the medicine of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and health products;
(2). As a strong antioxidant, it is widely used in cosmetics industry.


Why choose STAHERB for Magnolia Bark Extract(magnolol,honokiol,magnolol+honokiol)


1. Founded in 2010, Changsha staherb natural ingredients co.,ltd is a professional standardized plant extract manufacturer.

2.Hunan is the origin of Magnolia officinalis. Hunan is the most important production base of Magnolia officinalis in China. It is rich in wild resources. Changsha staherb and the local farmers have built a planting base of Magnolia officinalis with sufficient raw materials. Changsha staherbs  Magnolia production workshop is located in the raw material base, with better quality control of raw materials, lower production cost and better price.

3.Magnolia officinalis extract is the main product of Changsha Staherb, which is produced throughout the year, with stable quality and spot supply.

4.Staherb has a complete set of quality testing equipment and system, quality assurance.

5.The Magnolia officinalis extract of Staherb is produced by supercritical CO2 extraction technology, with large production and good quality control. No organic reagent is used in the extraction process, so the product quality is better and safer

6.Staherb Magnolia extract series products include: Magnolia+honokiol 1-98%, Magnolol 1-98%, and honokiol 1-98%, magnolia oil, magnolia oil extract, etc., full specifications products to meet your need.


For more product information pls contact email sales09@staherb.cn


1.K.Y. Ho C.C. Tsai C.P. Chen J.S. Huang C.C. Lin (2001) Phytother Res 15 2 139 10.1002/ptr.736 1:CAS:528:DC%2BD3MXjtVSgtbs%3D 11268114
2.K.H. Bang Y.K. Kim B.S. Min M.K. Na Y.H. Rhee J.P. Lee K.H. Bae (2000) Arch Pharm. Res 23 46 1:CAS:528:DC%2BD3cXhs1Sisb4%3D 10728656
3.M. Fujita H. Itokawa Y. Sashida (1972) Chem Pharm. Bull 20 212 1:CAS:528:DyaE38XhtFars7c%3D
4.R.F. Squires J. Ai M.R. Witt P. Kahnberg E. Saederup O. Sterner M. Nielsen (1999) Neurochem. Res 24 12 1593 10.1023/A:1021116502548 1:CAS:528:DyaK1MXnsFSju70%3D 10591411
5.H. Kuribara E. Kishi M. Kimura S.T. Weintraub Y. Maruyama (2000) Pharm Biochem. Behavior 67 3 597 10.1016/S0091-3057(00)00401-9 1:CAS:528:DC%2BD3MXnslSntA%3D%3D
6.Y. Fukuyama K. Nakade Y. Minoshima R. Yokoyama H.F. Zhai Y. Mitsumoto (2002) Bioorg. Med. Chem. Lett 12 8 1163 10.1016/S0960-894X(02)00112-9 1:CAS:528:DC%2BD38XisFWgtr4%3D 11934579
7.Z.M. Jin Y.J. Pan J.G. Liu D.J. Xu (2000) J. Chem. Crystallogr 30 3 195 10.1023/A:1009587232221 1:CAS:528:DC%2BD3cXosVKrsb8%3D
8.F. Toda K. Tanaka T. Fujiwara (1990) Angew. Chem 102 689
9.M.J. Fullmer R.C. Haltiwanger N. Troupe D.S. Eggleston (1994) Acta Crystallogr C50 1966 1:CAS:528:DyaK2MXivVyntL4%3D
10.G. Ferguson C. Glidewell R.M. Gregson P.R. Meehan L.J. I.Patterson (1998) Acta Cryst B54 151 1:CAS:528:DyaK1cXivVemu70%3D
11.A. Katrusiak (2000) J. Mol. Struct 552 159 10.1016/S0022-2860(00)00475-0 1:CAS:528:DC%2BD3cXmslKksrk%3D
12.C.R. Sun Z.M. Jin (2002) Acta Cryst C58 o600 1:CAS:528:DC%2BD38XnsValu70%3D
13.M.C. Etter (1990) Acc Chem. Res 23 120 10.1021/ar00172a005 1:CAS:528:DyaK3cXhsFOgt74%3D
14.J. Bernstein R.E. Davis L. Shimoni N.L. Chang (1995) Angew. Chem. Int. Ed. Engl 34 1555 10.1002/anie.199515551 1:CAS:528:DyaK2MXns1altLk%3D
15.Steiner T. and Desiraju G.R. (1998). Chem.Commun. 891.
16.Crystal Structure of 1:1 Complex of Honokiol and 1,4-Diazabicyclo[2.2.2]octane: Separation of Honokiol by Molecular Recognition
Phenomenon of molecular recognition between honokiol and 1,4-diazabicyclo[2.2.2] ... is discovered, and applied to separation of honokiol from extract of magnolia bark. Effects of ... the yield and the purity wer...

Zhi Min Jin, Wei Fu, Yuang Jiang Pan… in Journal of inclusion phenomena and macrocy… (2005)

17.Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
Honokiol, a cell-permeable phenolic compound derived from ... autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission mediated by...

Hsiu-Jen Wang, Alexis G Martin, Po-Kuan Chao… in Journal of Biomedical Science (2013)

18.ArticleOpen Access
Erratum to: Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis
Arumugam Nagalingam, Jack L. Arbiser, Michael Y. Bonner… in Breast Cancer Research (2017)

19.Erratum to: A novel GSH responsive poly(alpha-lipoic acid) nanocarrier bonding with the honokiol-DMXAA conjugate for combination therapy
In the version of the article originally published in the volume 63, issue 2, 2020 of Sci China Mater (2020, 63 (2): 307–315, https://doi.org/10.1007/s40843-019-1183-0), the affiliations of two of the authors (Zh...

Zhilin Liu, Zhaohui Tang, Dawei Zhang, Jiatan Wu, Xinghui Si… in Science China Materials (2020)

20.Magnolol and Honokiol
Magnolol is derived from root bark and branch bark of magnolia or Magnolia officinalis. Magnolol shows many pharmacological effects, such as prolonging of central muscle relaxation, inhibition of the central nerv...

Hai-Guang Yang, Guan-Hua Du in Natural Small Molecule Drugs from Plants (2018)

21.Retraction Note to: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
This article [1] has been retracted at the request of the corresponding author because an Investigation Committee established by Kobe Gakuin University (Kobe, Japan) has found numerous discrepancies between th...

Shinichi Harada, Maya Kishimoto, Mana Kobayashi… in Journal of Natural Medicines (2020)

22.Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model
Honokiol is a major bioactive compound extracted from ... present study was designed to determine whether liposomal honokiol has the antitumor activity against human lung...

Qi-qi Jiang, Lin-yu Fan, Guang-li Yang, Wen-Hao Guo, Wen-li Hou, Li-juan Chen… in BMC Cancer (2008)

23.Pluronic F127-cyclodextrin conjugate micelles for encapsulation of honokiol
To overcome honokiol’s poor water solubility and investigate its ... cyclodextrin conjugate was synthesized and employed to prepare honokiol-loaded micelles through emulsion-solvent evaporation method. ... and di...

Runliang Feng, Peizong Deng, Feilong Zhou, Sijia Feng… in Journal of Nanoparticle Research (2018)

24.Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol
Honokiol is a pleiotropic natural compound isolated from Magnolia...and has multiple biological and clinically relevant effects, including anticancer and antimicrobial function. However, the antiviral activity of...

Shuai Liu, Long Li, Lingbing Tan, Xiaozhen Liang in Virologica Sinica (2019)

25.Preparation and characterization of honokiol nanoparticles
In this paper, honokiol nanoparticles were prepared by emulsion solvent evaporation method. The prepared honokiol nanoparticles were characterized by particle size distribution, ... and crystallography. Results s...

Ma Ling Gou, Mei Dai, Xing Yi Li… in Journal of Materials Science: Materials in… (2008)

26.Mesoporous silica-based electrochemical sensor for simultaneous determination of honokiol and magnolol
A kind of mesoporous SiO2 was synthesized using cationic surfactant as the structure-directing template. After that, the resulting mesoporous SiO2...was used to modify the carbon paste electrode (CPE). The electr...

Jun Zhao, Wensheng Huang, Xiaojiang Zheng in Journal of Applied Electrochemistry (2009)

27.Inhibitory Effects of Honokiol and Magnolol on Biofilm Formation by Acinetobacter baumannii
Acinetobacter baumannii...is a nosocomial pathogen that can survive unfavorable conditions, such as, desiccation, nutrient starvation, and antimicrobial treatment, and this is primarily due to its ability to form...

Sagar Kiran Khadke, Jin-Hyung Lee, Je-Tae Woo… in Biotechnology and Bioprocess Engineering (2019)

28.Mitochondrial Dysfunction Induced by Honokiol
Honokiol has shown the ability to induce the ... present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H+ and K+..., membrane potential, membrane ...

Jia-Xin Dong, Guang-Yuan Zhao, Qiu-Li-Yang Yu, Ran Li… in The Journal of Membrane Biology (2013)

29.Effects of Honokiol on Sepsis-Induced Acute Kidney Injury in an Experimental Model of Sepsis in Rats
Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis...(Houpo), has been sho...

Nan Li, Hua Xie, Longkai Li, Jing Wang, Ming Fang, Ning Yang, Hongli Lin in Inflammation (2014)

30.Synergistic effect of lysozyme on bactericidal activity of magnolol and honokiol against a cariogenic bacterium,Streptococcus mutans OMZ 176
A combination of magnolol or honokiol with lysozyme isolated from the egg white...Streptococcus mutans OMZ 176. The synergistic ratio increased with time dependence.

Kihwan Bae, Hongrock Oh in Archives of Pharmacal Research (1990)

31.Photocatalytic self-cleaning electrochemical sensor for honokiol based on a glassy carbon electrode modified with reduced graphene oxide and titanium dioxide
The authors describe the construction of a renewable electrochemical method for determination of honokiol in complex traditional Chinese herbs. A nanocomposite...−1 honokinol concentration range, and the detectio...

Yan Lei, Fan Yang, Yu-Tao Li, Lina Tang, Keli Chen, Guo-Jun Zhang in Microchimica Acta (2017)

32.Separation and determination of magnolol and honokiol inMagnolia officinalis bark by capillary zone electrophoresis
The effects of pH on separation parameters such as migration mobility, resolution, sensitivity, column efficiency and peak shape were emphatically studied. Better separation of magnolol and honokiol using capilla...

Ziping Zhang, Zhide Hu, Gengliang Yang in Microchimica Acta (1997)

33.RETRACTED ARTICLE: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
Honokiol, a constituent of Magnolia obovata..., has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotecti...

Shinichi Harada, Maya Kishimoto, Mana Kobayashi… in Journal of Natural Medicines (2012)

34.Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents
Honokiol, a major phenolic constituent of Magnolia sp...., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-...

Young-Soo Kim, Ji-Young Lee, Junho Park, Wangtaek Hwang… in Archives of Pharmacal Research (2010)

35.Certification of a new certified reference material of honokiol
Honokiol is the most important active pharmaceutical ingredient...Magnolia officinalis..., which is a famous traditional Chinese medicine and commonly used in clinical practice. In order to control the quality of...

Shiying Yang, Dezhi Yang, Kun Hu, Haohui Zhou… in Analytical and Bioanalytical Chemistry (2015)