Macleaya cordata extract chelerythrine

Produce name:Macleaya cordata Extrat

Latin name: Macleaya cordata (Willd.)R.Br.

Active ingredients:Total alkaloids,sanguinarine,chelerythrine.

Appearance:orange red  fine powder

Specification:Total alkaloids: 20%-60%;

                     Ratio product: 5:1, 10:1,20:1 TLC

                     sanguinarine 1-30%,chelerythrine:1-50%

Test Method:HPLC / TLC

 This product is made from Macleaya cordata (Willd.)R.Br, it is a green pollution-free plant extract. Sanguinarine and chelerythrine are the main components of it. It has a strong antimicrobial activity and wide antimicrobial spectrum, it has antimicrobial activity against coccus, bacillus, gram-positive and electronegative bacterium, and it has a stronger antimicrobial activity more than commonly berberine hydrochloride and penicillin against some bacteria. Use this product can help livestock effectively antimicrobial diarrhea, simulative bile and pancreatic secretion. This product is safe and effective. It is easy to dissolve in methanol and ethanol solution.

 

Macleaya cordata extract

Active

Ingredients

Specs

Test Method

Appearance

Solubility

Total alkaloids

60%

HPLC

Orange yellow powder

Soluble in

water 

Sanguinarine

40%

HPLC

Orange yellow powder

chelerythrine

20%

HPLC

Orange yellow powder

 

Macleaya cordata extract chelerythrine main function:

1.Antiscolic: The three kinds of biological total base in the product can kill nematodes

 2.killing maggot: can inhibit incubation of flyblows.The strongest parts with the effects on killing maggots are leaves and pericarp, then stems, the roots are the least. The effect of the product will not be influenced by drying.

 

3.Inhibitory effect on some bacteria and fungi.

 

Macleaya cordata extract chelerythrine application:

 

1.It is widely used in veterinary medicine filed.

2.It is widely used in feed additive field.

3.It is widely used in medicine field.

4.It is widely used in cosmetic field.

 

Why choose STAHERB for macleaya cordata extract 

1. Founded in 2010, Changsha staherb natural ingredients co.,ltd is a professional standardized plant extract manufacturer.

2. Hunan is the origin of macleaya cordata which is rich in wild resources, and staherb have built a macleaya cordata planting base with the local farmer, with sufficient raw material resources.

3. Macleaya extract is the main product of Changsha Staherb, which is produced all year round, with various specifications, stable quality and spot supply.

4. Changsha staherbhas a complete set of quality testing equipment and system, quality assurance

5. Staherb provide the suggestions on the use of macleaya cordata extract

6. The macleaya cordata production workshop of Changsha staherb is located in the raw material base, with better quality control of raw materials, lower production cost and better price.

7. Macleaya extract is widely used in Europe and China, with clear active ingredients and good effect.

 

For more product information pls contact email sales09@staherb.cn

 

References:

  1. 1.

    Lilley DMJ (1995) Proc Natl Acad Sci USA 92:7140–7142 

  2. 2.

    Hermann T, Patel DJ (2000) Structure 8:R47–R54 

  3. 3.

    Xi Z, Hwang GS, Goldberg IH, Harris JL, Pennington WT, Fouad FS, Qabaja G, Wright JM, Jones GB (2002) Chem Biol 9:925–931

  4. 4.

    Nakatani K, Horie S, Murase T, Hagihara S, Saito I (2003) Bioorg Med Chem 11:2347–2353 

  5. 5.

    Nakatani K, Sando S, Saito I (2000) J Am Chem Soc 122:2172–2177

  6. 6.

    Xi Z, Goldberg IH (2002) Enediyne antibiotic neocarzinostatin as a radical-based probe of bulged structures in nucleic acids. In: Jones GB, Chapman BJ (eds) Advances in DNA sequence-specific agents. Elsevier, Amsterdam, Netherlands

  7. 7.

    Malkov VA, Biswas I, Camerini-Otero D, Hsieh P (1997) J Biol Chem 272:23811–23817

  8. 8.

    Wang YH, Bortner CD, Griffith J (1993) J Biol Chem 268:17571–17577

  9. 9.

    Lilley DMS (1995) Proc Natl Acad Sci USA 92:7140–7142

  10. 10.

    Dingwall C, Ernberg I, Gait MJ, Gree SM, Heaphy S, Karn J, Lowe AD, Singh M, Skinner MA, Valerio R (1989) Proc Natl Acad Sci USA 86:6925–6929

  11. 11.

    Greenblatt J, Nodwell JR, Mason SW (1993) Nature 364:401–406

  12. 12.

    Wells RD (1996) J Biol Chem 27:2875–2878

  13. 13.

    Perutz MF (1996) Curr Opin Struct Biol 6:848–858

  14. 14.

    Kunkel TA (1993) Nature 365:207–209

  15. 15.

    Harvey SC (1997) Biochemistry 36:3047–3049

  16. 16.

    Kappen LS, Xi Z, Jones GB, Goldberg IH (2003) Biochemistry 42:2166–2173

  17. 17.

    Ashley CT, Warren ST (1995) Annu Rev Genetics 29:703–728

  18. 18.

    Adhami VM, Aziz MH, Reagan-Shaw SR (2004) Mol Cancer Ther 3:933–940

  19. 19.

    Ahmad N, Gupta S, Husain MM, Heiskanen KM, Mukhtar H (2000) Clin Cancer Res 6:1524–1528

  20.  

    20.

    Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Ralph R (2000) Clin Cancer Res 6:737–742

     

  21. 21.

    Bai LP, Zhao ZZ, Cai Z, Jiang ZH (2006) Bioorg Med Chem 14:5439–544 

  22. 22.

    Xi Z, Zhang R, Yu Z, Ouyang D, Huang R (2005) Bioorg Med Chem Lett 15:2673–2677 

  23. 23.

    Bai LP, Zhao ZZ, Cai Z, Jiang ZH (2006) Nucleic Acids Symp Ser 50:197–198

  24. 24.

    Schneider HJ, Yatsimirsky AK (2000) Principles and methods in supramolecular chemistry. Wiley, New York

  25. 25.

    Wan KX, Shibue T, Gross M (2000) J Am Chem Soc 122:300–307

  26. 26.

    Chen WH, Chan CL, Cai Z, Luo GA, Jiang ZH (2004) Bioorg Med Chem Lett 14:4955–4959

  27. 27.

    Moody EM, Bevilacqua PC (2004) J Am Chem Soc 126:9570–9577

  28. 28.

    Qin Y, Pang JY, Chen WH, Cai Z, Jiang ZH (2006) Bioorg Med Chem 14:25–32

  29. 29.

    Long YH, Bai LP, Qin Y, Pang JY, Chen WH, Cai Z, Xu ZL, Jiang ZH (2006) Bioorg Med Chem 14:4670–4676

  30. 30.

    Senior MM, Jones RA, Breslauer KJ (1988) Proc Natl Acad Sci USA 85:6242–6246

  31. 31.

    Rosu F, Pirotte S, De Pauw E, Gabelica V (2006) Int J Mass Spectrum 253:156–171

  32. 32.

    Carrasco C, Rosu F, Gabelica V, Houssier C, De Pauw E, Garbay-Jaureguiberry C, Roques B, Wilson WD, Chaires JB, Waring MJ, Bailly C (2002) ChemBioChem 3:1235–1241

  33. 33.

    Rosu F, De Pauw E, Guittat L, Alberti P, Lacroix L, Mailliet P, Riou JF, Mergny JL (2003) Biochemistry 42:10361–10371

  34. 34.

    Jones GB, Lin Y, Xiao Z, Kappen L, Goldberg IH (2007) Bioorg Med Chem 15:784–790

  35. 35.

    Xi Z, Zhang R, Yu Z, Ouyang D (2006) Bioorg Med Chem Lett 16:4300–4304