About chamomile extract
Chamomile is the common name for several daisy-like plants of the family asteraceae, that are commonly used to make herb infusion that can help to induce sleep. Because chamomile can cause uterine contractions that can cause miscarriage, it should not be taken during pregnancy or breast-feeding.
Apigenin is a natural antioxidant, which can inhibit the activity of carcinogenic substances; as an antiviral drug to treatment for HIV and other virus-infected; treat various inflammations; calm and soothe the nerves; buck. Compared With other flavonoids (quercetin, kaempferol flavonoids), Apigenin is low toxicity and no mutagenicity.
Apigenin main function:
1. Chamomoile extract apigenin has long been used as an after-meal and bedtime drink;
2. Chamomile extract apigenin used for it's soothing effects and ability to support normal tone in the digestive tract;
3. Chamomoile extract apigenin used for a variety of ailments including: colic (especially in children), bloat,mild upper respiratory infections,premenstrual pain, anxiety and insomnia;
4. Chamomilr extract apigenin treat sore and chapped nipples in nursing mothers, as well as minor skin infections and abrasions. Eye drops made from these herbs are also used for tired eyes and mild ocular infections.
1.It is used in the food industry as a spice for meat dishes, and is used in soups and sauces.
2.In natural medicine, it is used as diureticum against bladder and kidney trouble and for therapy against inflammation.
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Apigenin seems to be very safe chemical, without any dangerous side effects, flavonoid can interact with chemotherapy drugs.It is, by itself, a potent chemotherapeutic agent.
5. Dosage Information
For general health and well-being, doses found in multiple servings of fruits and vegetables is adequate.For anxiolytic effects, doses in the range of 3-10 mg/kg bodyweight are effective without sedation, and higher doses induce sedation in addition to reductions in anxiety.
1.Abebe W (2002) Herbal medicine: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 27:391–401
2.Bortner CD, Cidlowski JA (1998) A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol 56:1549–1559
3.Bortner CD, Cidlowski JA (2007) Cell shrinkage and monovalent cation fluxes: role in apoptosis. Arch Biochem Biophys 462:176–188
4.Chikahisa L, Oyama Y, Okazaki E, Noda K (1996) Fluorescent estimation of H2O2-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes. Jpn J Pharmacol 71:299–305
5.Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1–16
6.Foti C, Netti E, Panebianco R, Cassano N, Diaferio A, Pia DP (2000) Contact urticaria from Matricaria chamomilla. Conatct Dermatitis 42:522–525
7.Fujimoto A, Sakanashi Y, Matsui M, Oyama TB, Nishimura Y, Masuda T, Oyama Y (2009) Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: potent cytotoxicity of resveratrol to normal cells. Basic Clin Pharmacol Toxicol 104:455–462
8.Galati G, Teng S, Moridani MY, Chan TS, O’Brien PJ (2000) Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact 17:311–349
9.Graf J (2000) Herbal anti-inflammatory agents for skin disease. Skin Therapy Lett 5(4):3–5
10.Iwase K, Tatsuishi T, Nishimura Y, Yamaguchi JY, Oyama Y, Miyoshi N, Wada M (2004) Cytometric analysis of adverse action of diphenyl ditelluride on rat thymocytes: cell shrinkage as a cytotoxic parameter. Environ Toxicol 19:614–619
11.Kim WJ, Mohan RR, Mohan RR, Wilson SE (2000) Caspase inhibitor z-VAD-FMK inhibits keratocyte apoptosis, but promotes keratocyte necrosis, after corneal epithelial scrape. Exp Eye Res 71:225–232
12.Kobayashi Y, Nakano Y, Inayama K, Sakai A, Kamiya T (2003) Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice. Phytomedicine 10:657–664
13.Kobayashi Y, Takahashi R, Ogino F (2005) Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice. J Ethnopharmacol 101:308–312
14.Kobayashi Y, Suzuki A, Kobayashi A, Ayaka-Kasai A, Ogata Y, Kumada Y, Takahashi R, Ogino F (2007) Suppression of sensory irritation by chamomile essential oil and its active component—Bisabololoxide A. Acta Hort (ISHS) 749:163–174
15.Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415–1420
16.Lambert JD, Yang CS (2003) Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat Res 523–4:201–208
17.Larzelere MM, Wiseman P (2002) Anxiety, depression, and insomnia. Prim Care 29:339–360
18.Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, Green DR (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182:1545–1556
19.Matos FJA, Machado MIL, Alencar JW, Craveiro AA (1993) Constituents of Brazilian chamomile oil. J Essent Oil Res 5:337–339
20.Mazzio EA, Soliman KF (2009) In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res 23:385–398
21.McConkey DJ, Jondal M, Orrenius S (1994) The regulation of apoptosis in thymocytes. Biochem Soc Trans 22:606–610
22.McKay DL, Blumberg JB (2006) A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res 20:519–530
23.Mimica-Dukic N, Lukic V, Pavkov R, Gasic O (1993) Study of chemical composition and microbiological contamination of chamomile tea. Acta Hortic 333:137–141
24.Nakao H, Umebayashi C, Nakata M, Nishizaki Y, Noda K, Okano Y, Oyama Y (2003) Formaldehyde-induced shrinkage of rat thymocytes. J Pharmacol Sci 91:83–86
25.Nakata M, Oyama Y, Chikahisa L, Yamazaki Y, Satoh M (1999) Flow cytometric analysis on tri-n-butyltin-induced increase in annexin V binding to membranes of rat thymocytes. Environ Toxicol Pharmacol 7:267–273
26.Nichenametla SN, Taruscio TG, Barney DL, Exon JH (2006) A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 46:161–183
27.Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Meth 139:271–279
28.Nishimura Y, Kanada A, Yamaguchi JY, Horimoto K, Kobayashi M, Tatsuishi T, Kanemaru K, Ueno SY, Oyama Y (2006) Cytometric analysis of -induced cytotoxicity: a model experiment using rat thymocytes. Toxicol 218:48–57
29.O’Hara M, Kiefer D, Farrell K, Kemper K (1998) A review of 12 commonly used medicinal herbs. Arch Fam Med 7:523–536
30.Okazaki E, Chikahisa L, Kanemaru K, Oyama Y (1996) Flow cytometric analysis on the H2O2-induced increase in intracellular Ca2+ concentration of rat thymocytes. Jpn J Pharmacol 71:273–280
31.Okazaki E, Oyama Y, Chikahisa L, Nagano T, Katayama K, Sakamoto M (1997) Fluorescent estimation on cytotoxicity of methylmercury in dissociated rat cerebellar neurons: its comparison with ionomycin. Environ Toxicol Pharmacol 3:237–244
32.Oyama Y, Chikahisa L, Ueha T, Hatakeyama Y, Kokubun T (1995) Change in membrane permeability induced by amyloid beta-protein fragment 25-35 in brain neurons dissociated from the rats. Jpn J Pharmacol 68:77–83
33.Oyama Y, Noguchi S, Nakata M, Okada Y, Yamazaki Y, Funai M, Chikahisa L, Kanemaru K (1999) Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: inhibitory actions of deferoxamine and quercetin. Eur J Pharmacol 384:47–52
34.Patzelt-Wenczler R, Ponce-Pöschl E (2000) Proof of efficacy of Kamillosan(R) cream in atopic eczema. Eur J Med Res 5:171–175
35.Pereira F, Santos R, Pereira A (1997) Contact dermatitis from chamomile tea. Contact Dermatitis 36:307
36.Quaglino D, Ronchetti IP (2001) Cell death in the rat thymus: a mini review. Apoptosis 6:389–401
37.Reider N, Sepp N, Fritsch P, Weinlich G, Jensen-Jarolim E (2000) Anaphylaxis to camomile: clinical features and allergen cross-reactivity. Clin Exp Allergy 30:1436–1443
38.Rinner I, Felsner P, Hofer D, Globerson A, Schauenstein K (1996) Characterization of the spontaneous apoptosis of rat thymocytes in vitro. Int Arch Allergy Immunol 111:230–237
39.Slee EA, Zhu H, Chow SC, MacFarlane M, Nicholson DW, Cohen GM (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J 315:21–24
40.Srivastava JK, Gupta S (2007) Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells. J Agric Food Chem 55:9470–9478
41.Subiza J, Subiza JL, Hinojosa M, Garcia R, Jerez M, Valdivieso R, Subiza E (1989) Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 84:353–358
42.Telford WG, King LE, Fraker PJ (1992) Comparative evaluation of several DNA binding dyes in the detection of apoptosis associated chromatin degradation by flow cytometry. Cytometry 13:137–143
43.Tiso M, Gangemi R, Bargellesi-Severi A, Pizzolitto S, Fabbi M, Risso A (1995) Spontaneous apoptosis in human thymocytes. Am J Pathol 147:434–444
44.Ueha T, Oyama Y, Tomiyoshi F (1996) Cytotoxic action of tri-n-butyltin on cerebellar neurons dissociated from the rats: a flow cytometric study. Pharmacol Toxicol 78:404–408
45.Van Noorden CJ (2001) The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition. Acta Histochem 103:241–251
46.Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Meth 184:39–51
47.Bisabololoxide A, one of the main constituents in German chamomile extract, induces apoptosis in rat thymocytes
German chamomile (Matricaria recutita L.), one of the popular ingredients in herbal teas, has been traditionally used for medicinal purposes. Bisabololoxide A (BSBO) is one of the main constituents in this herb. ...
Ikuko Ogata, Takuya Kawanai, Erika Hashimoto, Yumiko Nishimura… in Archives of Toxicology (2009)
48.Usefulness of Transgenic Luminescent Bacteria in Direct Bioautographic Investigation of Chamomile Extracts
Direct bioautography performed with luminescence gene-tagged bacteria enables almost real-time detection of antimicrobial compounds in plant extracts. This method for the detection of chamomile (Matricaria recuti...
Ágnes M. Móricz, Ernő Tyihák, Péter G. Ott in JPC – Journal of Planar Chromatography – M… (2010)
49.Chamomile extract/coffea/commiphora molmol
Reactions Weekly (2017)
50.Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study
Despite being the most commonly used herbal for sleep disorders, chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and sa...
Suzanna M Zick, Benjamin D Wright, Ananda Sen… in BMC Complementary and Alternative Medicine (2011)
51.Biological activities of chamomile (Matricaria chamomile) flowers’ extract against the survival and egg laying of the cattle fever tick (Acari Ixodidae)
In the present work, the potential of acaricidal activity of chamomile flowers’ extract was studied against engorged Rhipicephalus annulatus tick under laboratory condition. For this purpose, the engorged females...
Khodadad Pirali-Kheirabadi… in Journal of Zhejiang University SCIENCE B (2007)
52.P02.118. Oral chamomile (Matricaria recutita) extract therapy of Generalized Anxiety Disorder (GAD): trial in progress
J Mao, R Derubeis, Q Li, J Baier… in BMC Complementary and Alternative Medicine (2012)
53.Chamomile Methanolic Extract Mitigates Small Bowel Inflammation and ROS Overload Related to the Intestinal Nematodes Infection in Mice
Chamomile (Matricaria recutita...L.) is a plant which has been reported to be effective in treating several parasitic and digestive diseases. The present study was conducted to evaluate the anthelmintic activity ...
Soumaya Hajaji, Mohamed-Amine Jabri, Dhouha Alimi, Mourad Rekik… in Acta Parasitologica (2019)
54.Chamomile decoction extract inhibits human neutrophils ROS production and attenuates alcohol-induced haematological parameters changes and erythrocytes oxidative stress in rat
The aim of this study was to evaluate the protective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against stimulated neutrophils ROS production...
Mohamed-Amine Jabri, Mamane Sani, Kais Rtibi… in Lipids in Health and Disease (2016)
55.Quantitative proteomics analysis of the treatment of asthma rats with total flavonoid extract from chamomile
Asthma is a chronic immune disease that has become a serious public health problem. The currently available medications are not ideal because of their limitations and side effects; hence, new target proteins and ...
Qian Li, Shengjun Zhao, Jun Lu, Xiaolong Kang, Gang Zhang… in Biotechnology Letters (2020)
56.In-Situ Clean-Up and OPLC Fractionation of Chamomile Flower Extract to Search Active Components by Bioautography
Bioassay-guided isolation of antibacterial components of chamomile flower methanol extract was performed by overpressured layer chromatography (OPLC...in-situ in the adsorbent bed after off-line sample applicatio...
Emil Mincsovics, Péter G. Ott, Ágnes Alberti… in JPC – Journal of Planar Chromatography – M… (2013)
57.The response of serum Glypican-4 levels and its potential regulatory mechanism to endurance training and chamomile flowers’ hydroethanolic extract in streptozotocin–nicotinamide-induced diabetic rats
Glypican-4 (GPC-4) is a novel adipomyokine that enhances insulin signaling. Glycosylphosphatidylinositol-specific phospholipase D (GPLD1) is thought to release GPC-4 and is itself an insulin-regulated enzyme. Ben...
Farzad Abdolmaleki, Ali Heidarianpour in Acta Diabetologica (2018)
58.Evaluation of the Extraction Efficiency of Biologically Active Compounds from Chamomile Flowers (Chamomilla recutita R.) Grown in the Samara Region by Extractants in the Subcritical State
Extracts of biologically active compounds (BACs) from chamomile flowers grown in the Samara region produced ... gravimetry. Identification of BACs in the produced extracts was carried out using reactive gas chrom...
L. V. Pavlova, I. A. Platonov, V. A. Kurkin… in Russian Journal of Physical Chemistry B (2018)