corosolic acid
Name(s): 2 alpha-hydroxy ursolic acid
Common Name(s): Glucosol , corosolic acid
Uses of Corosolic Acid
Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. However, there is a lack of clinical evidence to support these uses.
Corosolic Acid Dosing
Numerous commercial formulations are available, including tablets, capsules, hypoglycemic food products, and cosmetics. Most formulations are available in capsule form, containing 18% corosolic acid and derived from Lagerstroemia speciosa L. Manufacturer suggested dosage is 1 softgel by mouth 30 minutes before morning and evening meals. Softgel products are marketed for noninsulin dependent type 2 diabetic patients.
Contraindications
Avoid use with hypersensitivity to any of the plant sources of corosolic acid.
Pregnancy/Lactation
Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.
Corosolic Acid Interactions
Counsel patients with diabetes or those taking antidiabetic medications about potential additive effects if they are self-medicating with any oral corosolic dietary supplement.
Corosolic Acid Adverse Reactions
There is potential for skin rashes because the product may be derived from several plant species.
Toxicology
Toxicologic information regarding use in humans is lacking.
Corosolic acid is found in numerous plant species, including L. speciosa L., Tiarella polyphylla D. Don, Datisca cannabina L., Eriobotrya japonica (Thunb.) Lindl., and Perilla frutescens (L.) Britton.
History
Corosolic acid has numerous biological properties including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. 1 , 2 It is found in numerous plants species, particularly L. speciosa . 3 Most medical research focuses on the compounds efficacy in diabetes. Glucosol (or GlucoFit ) is a commercially available product primarily marketed in Japan and the United States as a dietary supplement for weight loss and blood sugar balance. 1 Corosolic acid is found in numerous cosmetic products, including creams, lotions, hair tonics, as well as in hypoglycemic health foods. 3 , 4 , 5
Chemistry
Corosolic acid is a naturally occurring pentacyclic triterpene also known as 2 alpha-hydroxy ursolic acid. 6 , 7 Chemical analyses focus on the study of corosolic acid and its derivatives as inhibitors of glycogen phosphorylases for potential development of antidiabetic agents. 1 , 6 There is documented commercial interest in improving the chemical production of corosolic acid and its esters. 8 , 9
Common Name(s): Glucosol , corosolic acid
Uses of Corosolic Acid
Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. However, there is a lack of clinical evidence to support these uses.
Corosolic Acid Dosing
Numerous commercial formulations are available, including tablets, capsules, hypoglycemic food products, and cosmetics. Most formulations are available in capsule form, containing 18% corosolic acid and derived from Lagerstroemia speciosa L. Manufacturer suggested dosage is 1 softgel by mouth 30 minutes before morning and evening meals. Softgel products are marketed for noninsulin dependent type 2 diabetic patients.
Contraindications
Avoid use with hypersensitivity to any of the plant sources of corosolic acid.
Pregnancy/Lactation
Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.
Corosolic Acid Interactions
Counsel patients with diabetes or those taking antidiabetic medications about potential additive effects if they are self-medicating with any oral corosolic dietary supplement.
Corosolic Acid Adverse Reactions
There is potential for skin rashes because the product may be derived from several plant species.
Toxicology
Toxicologic information regarding use in humans is lacking.
Corosolic acid is found in numerous plant species, including L. speciosa L., Tiarella polyphylla D. Don, Datisca cannabina L., Eriobotrya japonica (Thunb.) Lindl., and Perilla frutescens (L.) Britton.
History
Corosolic acid has numerous biological properties including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. 1 , 2 It is found in numerous plants species, particularly L. speciosa . 3 Most medical research focuses on the compounds efficacy in diabetes. Glucosol (or GlucoFit ) is a commercially available product primarily marketed in Japan and the United States as a dietary supplement for weight loss and blood sugar balance. 1 Corosolic acid is found in numerous cosmetic products, including creams, lotions, hair tonics, as well as in hypoglycemic health foods. 3 , 4 , 5
Chemistry
Corosolic acid is a naturally occurring pentacyclic triterpene also known as 2 alpha-hydroxy ursolic acid. 6 , 7 Chemical analyses focus on the study of corosolic acid and its derivatives as inhibitors of glycogen phosphorylases for potential development of antidiabetic agents. 1 , 6 There is documented commercial interest in improving the chemical production of corosolic acid and its esters. 8 , 9